| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-IL36R (1-116) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
IL1RL2 |
| Gene ID: |
8808 |
| Uniprot ID: |
ILRL2_HUMAN |
| Immunogen Region: |
1-116 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-116 of human IL36R (NP_003845.2). |
| Immunogen Sequence: |
MWSLLLCGLSIALPLSVTAD GCKDIFMKNEILSASQPFAF NCTFPPITSGEVSVTWYKNS SKIPVSKIIQSRIHQDETWI LFLPMEWGDSGVYQCVIKGR DSCHRIHVNLTVFEKH |
| Tissue Specificity | Expressed in synovial fibroblasts and articular chondrocytes. Expressed in keratinocytes and monocyte-derived dendritic cells. Expressed in monocytes and myeloid dendritic cells.at protein level. |
| Function | Receptor for interleukin-36 (IL36A, IL36B and IL36G). After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAPK and other pathways. The IL-36 signaling system is thought to be present in epithelial barriers and to take part in local inflammatory response.it is similar to the IL-1 system. Seems to be involved in skin inflammatory response by induction of the IL-23/IL-17/IL-22 pathway. |
| Protein Name | Interleukin-1 Receptor-Like 2Il-36 ReceptorIl-36rInterleukin-1 Receptor-Related Protein 2Il-1rrp2Il1r-Rp2 |
| Database Links | Reactome: R-HSA-9007892Reactome: R-HSA-9014826 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Interleukin-1 Receptor-Like 2 antibodyAnti-Il-36 Receptor antibodyAnti-Il-36r antibodyAnti-Interleukin-1 Receptor-Related Protein 2 antibodyAnti-Il-1rrp2 antibodyAnti-Il1r-Rp2 antibodyAnti-IL1RL2 antibodyAnti-IL1RRP2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
