Anti-IL1RL2 antibody (1-116) (STJ112130)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal IL36R (1-116) antibody for use in WB, IF, ICC and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | IL1RL2 |
| Gene ID | 8808 |
| Uniprot ID | ILRL2_HUMAN |
| Immunogen Region | 1-116 |
| Immunogen Sequence | MWSLLLCGLSIALPLSVTAD GCKDIFMKNEILSASQPFAF NCTFPPITSGEVSVTWYKNS SKIPVSKIIQSRIHQDETWI LFLPMEWGDSGVYQCVIKGR DSCHRIHVNLTVFEKH |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-116 of human IL36R (NP_003845.2). |
Additional Info
| Tissue Specificity | Expressed in synovial fibroblasts and articular chondrocytes. Expressed in keratinocytes and monocyte-derived dendritic cells. Expressed in monocytes and myeloid dendritic cells.at protein level. |
| Function | Receptor for interleukin-36 (IL36A, IL36B and IL36G). After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAPK and other pathways. The IL-36 signaling system is thought to be present in epithelial barriers and to take part in local inflammatory response.it is similar to the IL-1 system. Seems to be involved in skin inflammatory response by induction of the IL-23/IL-17/IL-22 pathway. |
| Protein Name | Interleukin-1 Receptor-Like 2Il-36 ReceptorIl-36rInterleukin-1 Receptor-Related Protein 2Il-1rrp2Il1r-Rp2 |
| Database Links | Reactome: R-HSA-9007892Reactome: R-HSA-9014826 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Interleukin-1 Receptor-Like 2 antibodyAnti-Il-36 Receptor antibodyAnti-Il-36r antibodyAnti-Interleukin-1 Receptor-Related Protein 2 antibodyAnti-Il-1rrp2 antibodyAnti-Il1r-Rp2 antibodyAnti-IL1RL2 antibodyAnti-IL1RRP2 antibody |
Information sourced from Uniprot.org