| Tissue Specificity | Expressed in synovial fibroblasts and articular chondrocytes. Expressed in keratinocytes and monocyte-derived dendritic cells. Expressed in monocytes and myeloid dendritic cells.at protein level. |
| Function | Receptor for interleukin-36 (IL36A, IL36B and IL36G). After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAPK and other pathways. The IL-36 signaling system is thought to be present in epithelial barriers and to take part in local inflammatory response.it is similar to the IL-1 system. Seems to be involved in skin inflammatory response by induction of the IL-23/IL-17/IL-22 pathway. |
| Protein Name | Interleukin-1 Receptor-Like 2Il-36 ReceptorIl-36rInterleukin-1 Receptor-Related Protein 2Il-1rrp2Il1r-Rp2 |
| Database Links | Reactome: R-HSA-9007892Reactome: R-HSA-9014826 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Interleukin-1 Receptor-Like 2 antibodyAnti-Il-36 Receptor antibodyAnti-Il-36r antibodyAnti-Interleukin-1 Receptor-Related Protein 2 antibodyAnti-Il-1rrp2 antibodyAnti-Il1r-Rp2 antibodyAnti-IL1RL2 antibodyAnti-IL1RRP2 antibody |
Information sourced from Uniprot.org
