Anti-IL12RB1 antibody (25-305) (STJ28115)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal IL12RB1 (25-305) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | IL12RB1 |
| Gene ID | 3594 |
| Uniprot ID | I12R1_HUMAN |
| Immunogen Region | 25-305 |
| Immunogen Sequence | RTSECCFQDPPYPDADSGSA SGPRDLRCYRISSDRYECSW QYEGPTAGVSHFLRCCLSSG RCCYFAAGSATRLQFSDQAG VSVLYTVTLWVESWARNQTE KSPEVTLQLYNSVKYEPPLG DIKVSKLAGQLRMEWETPDN QVGAEVQFRHRTPSSPWKLG DCGPQDDDTESCLCPLEMNV AQEFQLRRRQLGSQGSSWSK WSSPVCVPPENPPQPQVRFS VEQLGQDGRRRLTLKEQPT |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 25-305 of human IL12RB1 (NP_714912.1). |
Additional Info
| Function | Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Also associates with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade. |
| Protein Name | Interleukin-12 Receptor Subunit Beta-1Il-12 Receptor Subunit Beta-1Il-12r Subunit Beta-1Il-12r-Beta-1Il-12rb1Il-12 Receptor Beta ComponentCd Antigen Cd212 |
| Database Links | Reactome: R-HSA-9020591Reactome: R-HSA-9020933 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Interleukin-12 Receptor Subunit Beta-1 antibodyAnti-Il-12 Receptor Subunit Beta-1 antibodyAnti-Il-12r Subunit Beta-1 antibodyAnti-Il-12r-Beta-1 antibodyAnti-Il-12rb1 antibodyAnti-Il-12 Receptor Beta Component antibodyAnti-Cd Antigen Cd212 antibodyAnti-IL12RB1 antibodyAnti-IL12R antibodyAnti-IL12RB antibody |
Information sourced from Uniprot.org