• STJ71292 (0. 02µg/ml) staining of Human Breast Cancer lysate (35µg protein in RIPA buffer) with (B) and without (A) blocking with the immunising peptide. Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-IGFBP3 antibody (Internal) (STJ71292)

SKU:
STJ71292-100

£303.50
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Host: Goat
Applications: Pep-ELISA/WB
Reactivity: Human/Mouse/Rat/Dog
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Goat polyclonal antibody anti-IGFBP3 (Internal) is suitable for use in ELISA and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 0.5 mg/mL
Dilution Range: WB-0.02-0.06µg/ml
ELISA-antibody detection limit dilution 1:64000.
Storage Instruction: Store at-20°C on receipt and minimise freeze-thaw cycles.
Gene Symbol: IGFBP3
Gene ID: 3486
Uniprot ID: IBP3_HUMAN
Immunogen Region: Internal
Accession Number: NP_001013416.1; NP_000589.2
Specificity: This antibody is expected to recognise both reported isoforms (NP_001013416.1 and NP_000589.2).
Immunogen Sequence: RYKVDYESQSTDTQN
Post Translational Modifications Phosphorylated by FAM20C in the extracellular medium.
Function IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R. Inhibits the positive effect of humanin on insulin sensitivity. Promotes testicular germ cell apoptosis.
Protein Name Insulin-Like Growth Factor-Binding Protein 3
Ibp-3
Igf-Binding Protein 3
Igfbp-3
Database Links Reactome: R-HSA-381426
Reactome: R-HSA-6803211
Reactome: R-HSA-8957275
Cellular Localisation Secreted
Alternative Antibody Names Anti-Insulin-Like Growth Factor-Binding Protein 3 antibody
Anti-Ibp-3 antibody
Anti-Igf-Binding Protein 3 antibody
Anti-Igfbp-3 antibody
Anti-IGFBP3 antibody
Anti-IBP3 antibody

Information sourced from Uniprot.org

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