Host: |
Goat |
Applications: |
Pep-ELISA/WB |
Reactivity: |
Human/Mouse/Rat/Dog |
Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: |
Goat polyclonal antibody anti-IGFBP3 (Internal) is suitable for use in ELISA and Western Blot research applications. |
Clonality: |
Polyclonal |
Conjugation: |
Unconjugated |
Isotype: |
IgG |
Formulation: |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
Purification: |
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
Concentration: |
0.5 mg/mL |
Dilution Range: |
WB-0.02-0.06µg/mlELISA-antibody detection limit dilution 1:64000. |
Storage Instruction: |
Store at-20°C on receipt and minimise freeze-thaw cycles. |
Gene Symbol: |
IGFBP3 |
Gene ID: |
3486 |
Uniprot ID: |
IBP3_HUMAN |
Immunogen Region: |
Internal |
Accession Number: |
NP_001013416.1; NP_000589.2 |
Specificity: |
This antibody is expected to recognise both reported isoforms (NP_001013416.1 and NP_000589.2). |
Immunogen Sequence: |
RYKVDYESQSTDTQN |
Post Translational Modifications | Phosphorylated by FAM20C in the extracellular medium. |
Function | IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R. Inhibits the positive effect of humanin on insulin sensitivity. Promotes testicular germ cell apoptosis. |
Protein Name | Insulin-Like Growth Factor-Binding Protein 3Ibp-3Igf-Binding Protein 3Igfbp-3 |
Database Links | Reactome: R-HSA-381426Reactome: R-HSA-6803211Reactome: R-HSA-8957275 |
Cellular Localisation | Secreted |
Alternative Antibody Names | Anti-Insulin-Like Growth Factor-Binding Protein 3 antibodyAnti-Ibp-3 antibodyAnti-Igf-Binding Protein 3 antibodyAnti-Igfbp-3 antibodyAnti-IGFBP3 antibodyAnti-IBP3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance