• Western blot analysis of extracts of various cell lines, using IFNL1 antibody (STJ110587) at 1:1000 dilution. _Secondary antibody: HRP Goat Anti-rabbit IgG (H+L) at 1:10000 dilution. _Lysates/proteins: 25ug per lane. _Blocking buffer: 3% non-fat dry milk in TBST. _Detection: ECL Enhanced Kit. _Exposure time: 20s.
  • Immunohistochemistry analysis of paraffin-embedded human stomach using IFNL1 antibody (STJ110587) at dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7. 2 before commencing with immunohistochemistry staining protocol.
  • Immunohistochemistry of paraffin-embedded human stomach using IFNL1 antibody (STJ110587) at dilution of 1:100 (40x lens).
  • Western blot analysis of extracts of various cell lines, using IFNL1 antibody (STJ110587) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 20s.

Anti-IFNL1 antibody (20-200) (STJ110587)

SKU:
STJ110587

£112.50 - £522.50
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Host: Rabbit
Applications: WB/IHC
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-IFNL1 (20-200) is suitable for use in Western Blot and Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
IHC-P 1:100-1:200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: IFNL1
Gene ID: 282618
Uniprot ID: IFNL1_HUMAN
Immunogen Region: 20-200
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 20-200 of human IFNL1 (NP_742152.1).
Immunogen Sequence: GPVPTSKPTTTGKGCHIGRF KSLSPQELASFKKARDALEE SLKLKNWSCSSPVFPGNWDL RLLQVRERPVALEAELALTL KVLEAAAGPALEDVLDQPLH TLHHILSQLQACIQPQPTAG PRPRGRLHHWLHRLQEAPKK ESAGCLEASVTFNLFRLLTR DLKYVADGNLCLRTSTHPES T
Function Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.
Protein Name Interferon Lambda-1
Ifn-Lambda-1
Cytokine Zcyto21
Interleukin-29
Il-29
Database Links Reactome: R-HSA-449836
Reactome: R-HSA-8854691
Cellular Localisation Secreted
Alternative Antibody Names Anti-Interferon Lambda-1 antibody
Anti-Ifn-Lambda-1 antibody
Anti-Cytokine Zcyto21 antibody
Anti-Interleukin-29 antibody
Anti-Il-29 antibody
Anti-IFNL1 antibody
Anti-IL29 antibody
Anti-ZCYTO21 antibody

Information sourced from Uniprot.org

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