| Host: |
Rabbit |
| Applications: |
WB/IHC-P/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000IHC-P:1:100-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
IFNL1 |
| Gene ID: |
282618 |
| Uniprot ID: |
IFNL1_HUMAN |
| Immunogen Region: |
20-200 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 20-200 of human IFNL1 (NP_742152.1). |
| Immunogen Sequence: |
GPVPTSKPTTTGKGCHIGRF KSLSPQELASFKKARDALEE SLKLKNWSCSSPVFPGNWDL RLLQVRERPVALEAELALTL KVLEAAAGPALEDVLDQPLH TLHHILSQLQACIQPQPTAG PRPRGRLHHWLHRLQEAPKK ESAGCLEASVTFNLFRLLTR DLKYVADGNLCLRTSTHPES T |
| Function | Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression. |
| Protein Name | Interferon Lambda-1Ifn-Lambda-1Cytokine Zcyto21Interleukin-29Il-29 |
| Database Links | Reactome: R-HSA-449836Reactome: R-HSA-8854691 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Interferon Lambda-1 antibodyAnti-Ifn-Lambda-1 antibodyAnti-Cytokine Zcyto21 antibodyAnti-Interleukin-29 antibodyAnti-Il-29 antibodyAnti-IFNL1 antibodyAnti-IL29 antibodyAnti-ZCYTO21 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
