| Function | Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression. |
| Protein Name | Interferon Lambda-1Ifn-Lambda-1Cytokine Zcyto21Interleukin-29Il-29 |
| Database Links | Reactome: R-HSA-449836Reactome: R-HSA-8854691 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Interferon Lambda-1 antibodyAnti-Ifn-Lambda-1 antibodyAnti-Cytokine Zcyto21 antibodyAnti-Interleukin-29 antibodyAnti-Il-29 antibodyAnti-IFNL1 antibodyAnti-IL29 antibodyAnti-ZCYTO21 antibody |
Information sourced from Uniprot.org
