| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | IFNGR2 |
| Gene ID: | 3460 |
| Uniprot ID: | INGR2_HUMAN |
| Immunogen Region: | 221-322 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 221-322 of human IFNGR2 (NP_005525.2). |
| Immunogen Sequence: | SNIFRVGHLSNISCYETMAD ASTELQQVILISVGTFSLLS VLAGACFFLVLKYRGLIKYW FHTPPSIPLQIEEYLKDPTQ PILEALDKDSSPKDDVWDSV SI |
| Tissue Specificity | Expressed in T-cells (at protein level). |
| Function | Associates with IFNGR1 to form a receptor for the cytokine interferon gamma (IFNG). Ligand binding stimulates activation of the JAK/STAT signaling pathway. Required for signal transduction in contrast to other receptor subunit responsible for ligand binding. |
| Protein Name | Interferon Gamma Receptor 2 Ifn-Gamma Receptor 2 Ifn-Gamma-R2 Interferon Gamma Receptor Accessory Factor 1 Af-1 Interferon Gamma Receptor Beta-Chain Ifn-Gamma-R-Beta Interferon Gamma Transducer 1 |
| Database Links | Reactome: R-HSA-877300 Reactome: R-HSA-877312 Reactome: R-HSA-9679191 Reactome: R-HSA-9732724 |
| Cellular Localisation | Cell Membrane Single-Pass Type I Membrane Protein Cytoplasmic Vesicle Membrane Golgi Apparatus Membrane Endoplasmic Reticulum Membrane Cytoplasm Has Low Cell Surface Expression And High Cytoplasmic Expression In T Cells The Bias Towards Cytoplasmic Expression May Be Due To Ligand-Independent Receptor Internalization And Recycling |
| Alternative Antibody Names | Anti-Interferon Gamma Receptor 2 antibody Anti-Ifn-Gamma Receptor 2 antibody Anti-Ifn-Gamma-R2 antibody Anti-Interferon Gamma Receptor Accessory Factor 1 antibody Anti-Af-1 antibody Anti-Interferon Gamma Receptor Beta-Chain antibody Anti-Ifn-Gamma-R-Beta antibody Anti-Interferon Gamma Transducer 1 antibody Anti-IFNGR2 antibody Anti-IFNGT1 antibody |
Information sourced from Uniprot.org