Anti-IFNGR2 antibody (221-322) (STJ116437)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal IFNGR2 (221-322) antibody for use in WB and ELISA in human and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | IFNGR2 |
| Gene ID | 3460 |
| Uniprot ID | INGR2_HUMAN |
| Immunogen Region | 221-322 |
| Immunogen Sequence | SNIFRVGHLSNISCYETMAD ASTELQQVILISVGTFSLLS VLAGACFFLVLKYRGLIKYW FHTPPSIPLQIEEYLKDPTQ PILEALDKDSSPKDDVWDSV SI |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 221-322 of human IFNGR2 (NP_005525.2). |
Additional Info
| Tissue Specificity | Expressed in T-cells (at protein level). |
| Function | Associates with IFNGR1 to form a receptor for the cytokine interferon gamma (IFNG). Ligand binding stimulates activation of the JAK/STAT signaling pathway. Required for signal transduction in contrast to other receptor subunit responsible for ligand binding. |
| Protein Name | Interferon Gamma Receptor 2Ifn-Gamma Receptor 2Ifn-Gamma-R2Interferon Gamma Receptor Accessory Factor 1Af-1Interferon Gamma Receptor Beta-ChainIfn-Gamma-R-BetaInterferon Gamma Transducer 1 |
| Database Links | Reactome: R-HSA-877300Reactome: R-HSA-877312Reactome: R-HSA-9679191Reactome: R-HSA-9732724 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinCytoplasmic Vesicle MembraneGolgi Apparatus MembraneEndoplasmic Reticulum MembraneCytoplasmHas Low Cell Surface Expression And High Cytoplasmic Expression In T CellsThe Bias Towards Cytoplasmic Expression May Be Due To Ligand-Independent Receptor Internalization And Recycling |
| Alternative Antibody Names | Anti-Interferon Gamma Receptor 2 antibodyAnti-Ifn-Gamma Receptor 2 antibodyAnti-Ifn-Gamma-R2 antibodyAnti-Interferon Gamma Receptor Accessory Factor 1 antibodyAnti-Af-1 antibodyAnti-Interferon Gamma Receptor Beta-Chain antibodyAnti-Ifn-Gamma-R-Beta antibodyAnti-Interferon Gamma Transducer 1 antibodyAnti-IFNGR2 antibodyAnti-IFNGT1 antibody |
Information sourced from Uniprot.org