| Short Description : | Rabbit polyclonal IFI30 (1-250) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | IFI30 |
| Gene ID: | 10437 |
| Uniprot ID: | GILT_HUMAN |
| Immunogen Region: | 1-250 |
| Immunogen Sequence: | MTLSPLLLFLPPLLLLLDVP TAAVQASPLQALDFFGNGPP VNYKTGNLYLRGPLKKSNAP LVNVTLYYEALCGGCRAFLI RELFPTWLLVMEILNVTLVP YGNAQEQNVSGRWEFKCQHG EEECKFNKVEACVLDELDME LAFLTIVCMEEFEDMERSLP LCLQLYAPGLSPDTIMECAM GDRGMQLMHANAQRTDALQP PHEYVPWVTVNGKPLEDQTQ LLTLVCQLYQGKKPDVCPS |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human IFI30 (NP_006323.2). |
| Post Translational Modifications | N-glycosylated. Sugar chains contain mannose-6-phosphate. Synthesized as a 35 kDa precursor which is then processed into the mature 30 kDa form via cleavage of N-terminal and C-terminal propeptides. Processing of the precursor is mediated by multiple lysosomal proteases. |
| Function | Lysosomal thiol reductase that can reduce protein disulfide bonds. May facilitate the complete unfolding of proteins destined for lysosomal degradation. Plays an important role in antigen processing. Facilitates the generation of MHC class II-restricted epitodes from disulfide bond-containing antigen by the endocytic reduction of disulfide bonds. Also facilitates MHC class I-restricted recognition of exogenous antigens containing disulfide bonds by CD8+ T-cells or crosspresentation. |
| Protein Name | Gamma-Interferon-Inducible Lysosomal Thiol ReductaseGamma-Interferon-Inducible Protein Ip-30Legumaturain |
| Database Links | Reactome: R-HSA-2132295Reactome: R-HSA-877300 |
| Cellular Localisation | SecretedLysosome |
| Alternative Antibody Names | Anti-Gamma-Interferon-Inducible Lysosomal Thiol Reductase antibodyAnti-Gamma-Interferon-Inducible Protein Ip-30 antibodyAnti-Legumaturain antibodyAnti-IFI30 antibodyAnti-GILT antibodyAnti-IP30 antibody |
Information sourced from Uniprot.org
