Anti-IFI30 antibody (1-250) (STJ114964)

Name: Anti-IFI30 antibody (1-250) (STJ114964)
SKU: STJ114964
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityPolyclonal

HostRabbit

ConjugationUnconjugated

IsotypeIgG

STJ114964

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Short Description	Rabbit polyclonal IFI30 (1-250) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents.
Applications	WB/ELISA
Host	Rabbit
Reactivity	Human
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Polyclonal
Isotype	IgG
Conjugation	Unconjugated
Concentration	Lot specific
Purification	Affinity purification
Dilution Range	WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Formulation	PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3.
Storage Instruction	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol	IFI30
Gene ID	10437
Uniprot ID	GILT_HUMAN
Immunogen Region	1-250
Immunogen Sequence	MTLSPLLLFLPPLLLLLDVP TAAVQASPLQALDFFGNGPP VNYKTGNLYLRGPLKKSNAP LVNVTLYYEALCGGCRAFLI RELFPTWLLVMEILNVTLVP YGNAQEQNVSGRWEFKCQHG EEECKFNKVEACVLDELDME LAFLTIVCMEEFEDMERSLP LCLQLYAPGLSPDTIMECAM GDRGMQLMHANAQRTDALQP PHEYVPWVTVNGKPLEDQTQ LLTLVCQLYQGKKPDVCPS
Specificity	Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human IFI30 (NP_006323.2).

Post Translational Modifications	N-glycosylated. Sugar chains contain mannose-6-phosphate. Synthesized as a 35 kDa precursor which is then processed into the mature 30 kDa form via cleavage of N-terminal and C-terminal propeptides. Processing of the precursor is mediated by multiple lysosomal proteases.
Function	Lysosomal thiol reductase that can reduce protein disulfide bonds. May facilitate the complete unfolding of proteins destined for lysosomal degradation. Plays an important role in antigen processing. Facilitates the generation of MHC class II-restricted epitodes from disulfide bond-containing antigen by the endocytic reduction of disulfide bonds. Also facilitates MHC class I-restricted recognition of exogenous antigens containing disulfide bonds by CD8+ T-cells or crosspresentation.
Protein Name	Gamma-Interferon-Inducible Lysosomal Thiol Reductase Gamma-Interferon-Inducible Protein Ip-30 Legumaturain
Database Links	Reactome: R-HSA-2132295 Reactome: R-HSA-877300
Cellular Localisation	Secreted Lysosome
Alternative Antibody Names	Anti-Gamma-Interferon-Inducible Lysosomal Thiol Reductase antibody Anti-Gamma-Interferon-Inducible Protein Ip-30 antibody Anti-Legumaturain antibody Anti-IFI30 antibody Anti-GILT antibody Anti-IP30 antibody

Information sourced from Uniprot.org