Anti-ID2 antibody (1-100) (STJ11105624)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal Dna-Binding Protein Inhibitor Id-2 (1-100) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:1000-1:5000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ID2 |
| Gene ID | 3398 |
| Uniprot ID | ID2_HUMAN |
| Immunogen Region | 1-100 |
| Immunogen Sequence | MKAFSPVRSVRKNSLSDHSL GISRSKTPVDDPMSLLYNMN DCYSKLKELVPSIPQNKKVS KMEILQHVIDYILDLQIALD SHPTIVSLHHQRPGQNQASR |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human ID2 (NP_002157.2). |
Additional Info
| Tissue Specificity | Highly expressed in early fetal tissues, including those of the central nervous system. |
| Post Translational Modifications | Ubiquitinated in a ASB4-depedent manner, leading to proteasomal degradation. Phosphorylated in vitro by CDK1, PKA and PKC. |
| Function | Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. Restricts the CLOCK and BMAL1 localization to the cytoplasm. Plays a role in both the input and output pathways of the circadian clock: in the input component, is involved in modulating the magnitude of photic entrainment and in the output component, contributes to the regulation of a variety of liver clock-controlled genes involved in lipid metabolism. |
| Protein Name | Dna-Binding Protein Inhibitor Id-2Class B Basic Helix-Loop-Helix Protein 26Bhlhb26Inhibitor Of Dna Binding 2Inhibitor Of Differentiation 2 |
| Database Links | Reactome: R-HSA-9031628 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Dna-Binding Protein Inhibitor Id-2 antibodyAnti-Class B Basic Helix-Loop-Helix Protein 26 antibodyAnti-Bhlhb26 antibodyAnti-Inhibitor Of Dna Binding 2 antibodyAnti-Inhibitor Of Differentiation 2 antibodyAnti-ID2 antibodyAnti-BHLHB26 antibody |
Information sourced from Uniprot.org