Anti-IBSP antibody (1-100) (STJ11103857)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal Bone Sialoprotein 2 (1-100) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | IBSP |
| Gene ID | 3381 |
| Uniprot ID | SIAL_HUMAN |
| Immunogen Region | 1-100 |
| Immunogen Sequence | MKTALILLSILGMACAFSMK NLHRRVKIEDSEENGVFKYR PRYYLYKHAYFYPHLKRFPV QGSSDSSEENGDDSSEEEEE EEETSNEGENNEESNEDEDS |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human IBSP (NP_004958.2). |
Additional Info
| Tissue Specificity | Expressed in bone (at protein level). Expressed in trophoblast cells of placenta (at protein level). Expressed in brain. |
| Post Translational Modifications | N-glycosylated.glycans consist of sialylated and core-fucosylated bi-, tri- and tetraantennary chains. O-glycosylated at eight sites.mucin-type glycans contain Gal, GlcNAc, GalNAc and terminal NeuAc. |
| Function | Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes adhesion and migration of various cells via the alpha-V/beta-3 integrin receptor (ITGAV:ITGB3). |
| Protein Name | Integrin-Binding SialoproteinBone Sialoprotein 2Bone Sialoprotein IiBsp IiCell-Binding Sialoprotein |
| Database Links | Reactome: R-HSA-216083Reactome: R-HSA-3000178 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Integrin-Binding Sialoprotein antibodyAnti-Bone Sialoprotein 2 antibodyAnti-Bone Sialoprotein Ii antibodyAnti-Bsp Ii antibodyAnti-Cell-Binding Sialoprotein antibodyAnti-IBSP antibodyAnti-BNSP antibody |
Information sourced from Uniprot.org