Anti-IAPP antibody (1-89) (STJ24112)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal IAPP (1-89) antibody for use in WB, IHC-P, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000IHC-P:1:50-1:200IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | IAPP |
| Gene ID | 3375 |
| Uniprot ID | IAPP_HUMAN |
| Immunogen Region | 1-89 |
| Immunogen Sequence | MGILKLQVFLIVLSVALNHL KATPIESHQVEKRKCNTATC ATQRLANFLVHSSNNFGAIL SSTNVGSNTYGKRNAVEVLK REPLNYLPL |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 1-89 of human IAPP (NP_000406.1). |
Additional Info
| Post Translational Modifications | Amyloid fibrils are degraded by insulin-degrading enzyme IDE. |
| Function | Amylin/IAPP is a glucoregulatory peptide hormone that plays an important role in the regulation of energy homeostasis. Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism. IAPP function is mediated by the CALCR-RAMPs (AMYRs) receptor complexes. Amylin can also bind CALCR receptor in the absence of RAMPs, although it is more selective for AMYRs. |
| Protein Name | Islet Amyloid PolypeptideIappAmylinDiabetes-Associated PeptideDapInsulinoma Amyloid Peptide |
| Database Links | Reactome: R-HSA-210745Reactome: R-HSA-418555Reactome: R-HSA-419812Reactome: R-HSA-977225 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Islet Amyloid Polypeptide antibodyAnti-Iapp antibodyAnti-Amylin antibodyAnti-Diabetes-Associated Peptide antibodyAnti-Dap antibodyAnti-Insulinoma Amyloid Peptide antibodyAnti-IAPP antibody |
Information sourced from Uniprot.org