Anti-HYAL3 antibody (STJA0008263)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human HYAL3
General Information
| Short Description | Rabbit polyclonal anti-Hyaluronidase-3 for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | HYAL3 |
| Gene ID | 8372 |
| Uniprot ID | HYAL3_HUMAN |
| Immunogen | Synthesized peptide derived from human HYAL3 |
| Specificity | This antibody detects endogenous levels of HYAL3 at Human, Mouse, Rat |
Additional Info
| Post Translational Modifications | N-glycosylated. |
| Function | Facilitates sperm penetration into the layer of cumulus cells surrounding the egg by digesting hyaluronic acid. Involved in induction of the acrosome reaction in the sperm. Involved in follicular atresia, the breakdown of immature ovarian follicles that are not selected to ovulate. Induces ovarian granulosa cell apoptosis, possibly via apoptotic signaling pathway involving CASP8 and CASP3 activation, and poly(ADP-ribose) polymerase (PARP) cleavage. Has no hyaluronidase activity in embryonic fibroblasts in vitro. Has no hyaluronidase activity in granulosa cells in vitro. |
| Protein Name | Hyaluronidase-3Hyal-3Hyaluronoglucosaminidase-3Lung Carcinoma Protein 3Luca-3 |
| Database Links | Reactome: R-HSA-2024101Reactome: R-HSA-2160916 |
| Cellular Localisation | SecretedCell MembraneCytoplasmic VesicleSecretory VesicleAcrosomeEndoplasmic ReticulumEarly EndosomeMostly Present In Low-Density VesiclesLow Levels In Higher Density Vesicles Of Late Endosomes And LysosomesLocalized In Punctate Cytoplasmic Vesicles And In Perinuclear StructuresBut Does Not Colocalize With Lamp1Localized On The Plasma Membrane Over The Acrosome And On The Surface Of The Midpiece Of The Sperm Tail |
| Alternative Antibody Names | Anti-Hyaluronidase-3 antibodyAnti-Hyal-3 antibodyAnti-Hyaluronoglucosaminidase-3 antibodyAnti-Lung Carcinoma Protein 3 antibodyAnti-Luca-3 antibodyAnti-HYAL3 antibodyAnti-LUCA3 antibody |
Information sourced from Uniprot.org