| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Hyaluronidase-3 is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | HYAL3 |
| Gene ID: | 8372 |
| Uniprot ID: | HYAL3_HUMAN |
| Specificity: | This antibody detects endogenous levels of HYAL3 at Human, Mouse, Rat |
| Immunogen: | Synthesized peptide derived from human HYAL3 |
| Post Translational Modifications | N-glycosylated. |
| Function | Facilitates sperm penetration into the layer of cumulus cells surrounding the egg by digesting hyaluronic acid. Involved in induction of the acrosome reaction in the sperm. Involved in follicular atresia, the breakdown of immature ovarian follicles that are not selected to ovulate. Induces ovarian granulosa cell apoptosis, possibly via apoptotic signaling pathway involving CASP8 and CASP3 activation, and poly(ADP-ribose) polymerase (PARP) cleavage. Has no hyaluronidase activity in embryonic fibroblasts in vitro. Has no hyaluronidase activity in granulosa cells in vitro. |
| Protein Name | Hyaluronidase-3 Hyal-3 Hyaluronoglucosaminidase-3 Lung Carcinoma Protein 3 Luca-3 |
| Database Links | Reactome: R-HSA-2024101 Reactome: R-HSA-2160916 |
| Cellular Localisation | Secreted Cell Membrane Cytoplasmic Vesicle Secretory Vesicle Acrosome Endoplasmic Reticulum Early Endosome Mostly Present In Low-Density Vesicles Low Levels In Higher Density Vesicles Of Late Endosomes And Lysosomes Localized In Punctate Cytoplasmic Vesicles And In Perinuclear Structures But Does Not Colocalize With Lamp1 Localized On The Plasma Membrane Over The Acrosome And On The Surface Of The Midpiece Of The Sperm Tail |
| Alternative Antibody Names | Anti-Hyaluronidase-3 antibody Anti-Hyal-3 antibody Anti-Hyaluronoglucosaminidase-3 antibody Anti-Lung Carcinoma Protein 3 antibody Anti-Luca-3 antibody Anti-HYAL3 antibody Anti-LUCA3 antibody |
Information sourced from Uniprot.org