• Anti-Human IgG antibody [EBS-huG] (STJ16101012)

Anti-Human IgG antibody [EBS-huG] (STJ16101012)

SKU:
STJ16101012

£264.50 - £1,251.50
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Host: Mouse
Applications: ELISA/FC/IHC
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-Human IgG is suitable for use in ELISA, Flow Cytometry and Immunohistochemistry research applications.
Clonality: Monoclonal
Clone ID: EBS-huG
Conjugation: Unconjugated
Isotype: IgG2ak
Formulation: PBS with 0.02% Sodium Azide.
Purification: Affinity purified from tissue culture.
Concentration: Can be provided as 100 µg/mL, 500 µg/mL or 1mg/mL.
Dilution Range: ELISA (solid phase: 0, 1-100 µg/ml; tracer: 0, 001-100 µg/ml for 30 min at RT). Flow cytometry (0.5-1.0 µg/million cells in 0.1 ml). Immunohistology (1-2 µg/ml for 30 min at RT).
Storage Instruction: Store for up to 1 year at 2-8°C upon receipt.
Gene Symbol: FCGRT
Gene ID: 2217
Uniprot ID: FCGRN_HUMAN
Immunogen: A BALB/c mouse was immunized with purified human immunoglobulins. Fusion partner: SP2/0.
Tissue Specificity Expressed in full-term placenta, heart, lung, liver, muscle, kidney, pancreas, and both fetal and adult small intestine.
Function Cell surface receptor that transfers passive humoral immunity from the mother to the newborn. Binds to the Fc region of monomeric immunoglobulin gamma and mediates its selective uptake from milk. IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids. Throughout life, contributes to effective humoral immunity by recycling IgG and extending its half-life in the circulation. Mechanistically, monomeric IgG binding to FcRn in acidic endosomes of endothelial and hematopoietic cells recycles IgG to the cell surface where it is released into the circulation. In addition of IgG, regulates homeostasis of the other most abundant circulating protein albumin/ALB. (Microbial infection) Acts as an uncoating receptor for a panel of echoviruses including Echovirus 5, 6, 7, 9, 11, 13, 25 and 29.
Protein Name Igg Receptor Fcrn Large Subunit P51
Fcrn
Igg Fc Fragment Receptor Transporter Alpha Chain
Neonatal Fc Receptor
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Endosome Membrane
Alternative Antibody Names Anti-Igg Receptor Fcrn Large Subunit P51 antibody
Anti-Fcrn antibody
Anti-Igg Fc Fragment Receptor Transporter Alpha Chain antibody
Anti-Neonatal Fc Receptor antibody
Anti-FCGRT antibody
Anti-FCRN antibody

Information sourced from Uniprot.org

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