![Anti-Human IgG antibody [EBS-huG] (STJ16101012)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/149728/302469/STJ16101012_1__52509.1646940652.jpg?c=1 "Anti-Human IgG antibody [EBS-huG] (STJ16101012)")
![Anti-Human IgG antibody [EBS-huG] (STJ16101012)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/149728/302469/STJ16101012_1__52509.1646940652.jpg?c=1 "Anti-Human IgG antibody [EBS-huG] (STJ16101012)")
Anti-Human IgG antibody [EBS-huG] (STJ16101012)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG2ak
ImmunogenA BALB/c mouse was immunized with purified human immunoglobulins. Fusion partner: SP2/0.
General Information
| Short Description | Mouse monoclonal anti-Human IgG for use in ELISA, FC and IHC in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ELISA/FC/IHC |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | EBS-huG |
| Isotype | IgG2ak |
| Conjugation | Unconjugated |
| Concentration | Can be provided as 100 µg/mL, 500 µg/mL or 1mg/mL. |
| Purification | Affinity purified from tissue culture. |
| Dilution Range | ELISA (solid phase: 0, 1-100 µg/ml; tracer: 0, 001-100 µg/ml for 30 min at RT). Flow cytometry (0.5-1.0 µg/million cells in 0.1 ml). Immunohistology (1-2 µg/ml for 30 min at RT). |
| Formulation | PBS with 0.02% Sodium Azide. |
| Storage Instruction | Store for up to 1 year at 2-8°C upon receipt. |
Target Information
| Gene Symbol | FCGRT |
| Gene ID | 2217 |
| Uniprot ID | FCGRN_HUMAN |
| Immunogen | A BALB/c mouse was immunized with purified human immunoglobulins. Fusion partner: SP2/0. |
Additional Info
| Tissue Specificity | Expressed in full-term placenta, heart, lung, liver, muscle, kidney, pancreas, and both fetal and adult small intestine. |
| Function | Cell surface receptor that transfers passive humoral immunity from the mother to the newborn. Binds to the Fc region of monomeric immunoglobulin gamma and mediates its selective uptake from milk. IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids. Throughout life, contributes to effective humoral immunity by recycling IgG and extending its half-life in the circulation. Mechanistically, monomeric IgG binding to FcRn in acidic endosomes of endothelial and hematopoietic cells recycles IgG to the cell surface where it is released into the circulation. In addition of IgG, regulates homeostasis of the other most abundant circulating protein albumin/ALB. (Microbial infection) Acts as an uncoating receptor for a panel of echoviruses including Echovirus 5, 6, 7, 9, 11, 13, 25 and 29. |
| Protein Name | Igg Receptor Fcrn Large Subunit P51FcrnIgg Fc Fragment Receptor Transporter Alpha ChainNeonatal Fc Receptor |
| Database Links | |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinEndosome Membrane |
| Alternative Antibody Names | Anti-Igg Receptor Fcrn Large Subunit P51 antibodyAnti-Fcrn antibodyAnti-Igg Fc Fragment Receptor Transporter Alpha Chain antibodyAnti-Neonatal Fc Receptor antibodyAnti-FCGRT antibodyAnti-FCRN antibody |
Information sourced from Uniprot.org