Anti-HSD17B3 antibody (1-310) (STJ110000)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal HSD17B3 (1-310) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | HSD17B3 |
| Gene ID | 3293 |
| Uniprot ID | DHB3_HUMAN |
| Immunogen Region | 1-310 |
| Immunogen Sequence | MGDVLEQFFILTGLLVCLAC LAKCVRFSRCVLLNYWKVLP KSFLRSMGQWAVITGAGDGI GKAYSFELAKRGLNVVLISR TLEKLEAIATEIERTTGRSV KIIQADFTKDDIYEHIKEKL AGLEIGILVNNVGMLPNLLP SHFLNAPDEIQSLIHCNITS VVKMTQLILKHMESRQKGLI LNISSGIALFPWPLYSMYSA SKAFVCAFSKALQEEYKAKE VIIQVLTPYAVSTAMTKYL |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-310 of human HSD17B3 (NP_000188.1). |
Additional Info
| Tissue Specificity | Testis. |
| Function | Catalyzes the conversion of 17-oxosteroids to 17beta-hydroxysteroids. Favors the reduction of androstenedione to testosterone. Testosterone is the key androgen driving male development and function. Uses NADPH while the two other EDH17B enzymes use NADH. Androgens such as epiandrosterone, dehydroepiandrosterone, androsterone and androstanedione are accepted as substrates and reduced at C-17. Can reduce 11-ketoandrostenedione as well as 11beta-hydroxyandrostenedione at C-17 to the respective testosterone forms. |
| Protein Name | 17-Beta-Hydroxysteroid Dehydrogenase Type 317-Beta-Hsd 3Estradiol 17-Beta-Dehydrogenase 2Short Chain Dehydrogenase/Reductase Family 12c Member 2Testicular 17-Beta-Hydroxysteroid DehydrogenaseTestosterone 17-Beta-Dehydrogenase 3 |
| Database Links | Reactome: R-HSA-193048Reactome: R-HSA-75876 |
| Cellular Localisation | Endoplasmic Reticulum |
| Alternative Antibody Names | Anti-17-Beta-Hydroxysteroid Dehydrogenase Type 3 antibodyAnti-17-Beta-Hsd 3 antibodyAnti-Estradiol 17-Beta-Dehydrogenase 2 antibodyAnti-Short Chain Dehydrogenase/Reductase Family 12c Member 2 antibodyAnti-Testicular 17-Beta-Hydroxysteroid Dehydrogenase antibodyAnti-Testosterone 17-Beta-Dehydrogenase 3 antibodyAnti-HSD17B3 antibodyAnti-EDH17B3 antibodyAnti-SDR12C2 antibody |
Information sourced from Uniprot.org