| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-HSD17B3 (1-310) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
HSD17B3 |
| Gene ID: |
3293 |
| Uniprot ID: |
DHB3_HUMAN |
| Immunogen Region: |
1-310 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-310 of human HSD17B3 (NP_000188.1). |
| Immunogen Sequence: |
MGDVLEQFFILTGLLVCLAC LAKCVRFSRCVLLNYWKVLP KSFLRSMGQWAVITGAGDGI GKAYSFELAKRGLNVVLISR TLEKLEAIATEIERTTGRSV KIIQADFTKDDIYEHIKEKL AGLEIGILVNNVGMLPNLLP SHFLNAPDEIQSLIHCNITS VVKMTQLILKHMESRQKGLI LNISSGIALFPWPLYSMYSA SKAFVCAFSKALQEEYKAKE VIIQVLTPYAVSTAMTKYL |
| Tissue Specificity | Testis. |
| Function | Catalyzes the conversion of 17-oxosteroids to 17beta-hydroxysteroids. Favors the reduction of androstenedione to testosterone. Testosterone is the key androgen driving male development and function. Uses NADPH while the two other EDH17B enzymes use NADH. Androgens such as epiandrosterone, dehydroepiandrosterone, androsterone and androstanedione are accepted as substrates and reduced at C-17. Can reduce 11-ketoandrostenedione as well as 11beta-hydroxyandrostenedione at C-17 to the respective testosterone forms. |
| Protein Name | 17-Beta-Hydroxysteroid Dehydrogenase Type 317-Beta-Hsd 3Estradiol 17-Beta-Dehydrogenase 2Short Chain Dehydrogenase/Reductase Family 12c Member 2Testicular 17-Beta-Hydroxysteroid DehydrogenaseTestosterone 17-Beta-Dehydrogenase 3 |
| Database Links | Reactome: R-HSA-193048Reactome: R-HSA-75876 |
| Cellular Localisation | Endoplasmic Reticulum |
| Alternative Antibody Names | Anti-17-Beta-Hydroxysteroid Dehydrogenase Type 3 antibodyAnti-17-Beta-Hsd 3 antibodyAnti-Estradiol 17-Beta-Dehydrogenase 2 antibodyAnti-Short Chain Dehydrogenase/Reductase Family 12c Member 2 antibodyAnti-Testicular 17-Beta-Hydroxysteroid Dehydrogenase antibodyAnti-Testosterone 17-Beta-Dehydrogenase 3 antibodyAnti-HSD17B3 antibodyAnti-EDH17B3 antibodyAnti-SDR12C2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
