| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-HSD11B2 (266-405) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:200-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
HSD11B2 |
| Gene ID: |
3291 |
| Uniprot ID: |
DHI2_HUMAN |
| Immunogen Region: |
266-405 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 266-405 of human HSD11B2 (NP_000187.3). |
| Immunogen Sequence: |
KTESVRNVGQWEKRKQLLLA NLPQELLQAYGKDYIEHLHG QFLHSLRLAMSDLTPVVDAI TDALLAARPRRRYYPGQGLG LMYFIHYYLPEGLRRRFLQA FFISHCLPRALQPGQPGTTP PQDAAQDPNLSPGPSPAVAR |
| Tissue Specificity | Expressed in kidney, placenta, pancreas, prostate, ovary, small intestine and colon, and in lower levels in the spleen and testis. At midgestation, expressed at high levels in placenta and in fetal kidney and, at much lower levels, in fetal lung and testis. |
| Function | Catalyzes the conversion of biologically active 11beta-hydroxyglucocorticoids (11beta-hydroxysteroid) such as cortisol, to inactive 11-ketoglucocorticoids (11-oxosteroid) such as cortisone, in the presence of NAD(+). Functions as a dehydrogenase (oxidase), thereby decreasing the concentration of active glucocorticoids, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids. Plays an important role in maintaining glucocorticoids balance during preimplantation and protects the fetus from excessive maternal corticosterone exposure. Catalyzes the oxidation of 11beta-hydroxytestosterone (11beta,17beta-dihydroxyandrost-4-ene-3-one) to 11-ketotestosterone (17beta-hydroxyandrost-4-ene-3,11-dione), a major bioactive androgen. Catalyzes the conversion of 11beta-hydroxyandrostenedione (11beta-hydroxyandrost-4-ene-3,17-dione) to 11-ketoandrostenedione (androst-4-ene-3,11,17-trione), which can be further metabolized to 11-ketotestosterone. Converts 7-beta-25-dihydroxycholesterol to 7-oxo-25-hydroxycholesterol in vitro. 7-beta-25-dihydroxycholesterol (not 7-oxo-25-hydroxycholesterol) acts as ligand for the G-protein-coupled receptor (GPCR) Epstein-Barr virus-induced gene 2 (EBI2) and may thereby regulate immune cell migration. May protect ovulating oocytes and fertilizing spermatozoa from the adverse effects of cortisol. |
| Protein Name | 11-Beta-Hydroxysteroid Dehydrogenase Type 211-Dh211-Beta-Hsd211-Beta-Hydroxysteroid Dehydrogenase Type Ii11-Hsd Type Ii11-Beta-Hsd Type IiCorticosteroid 11-Beta-Dehydrogenase Isozyme 2Nad-Dependent 11-Beta-Hydroxysteroid DehydrogenaseShort Chain Dehydrogenase/Reductase Family 9c Member 3 |
| Database Links | Reactome: R-HSA-194002Reactome: R-HSA-9757110 |
| Cellular Localisation | MicrosomeEndoplasmic Reticulum |
| Alternative Antibody Names | Anti-11-Beta-Hydroxysteroid Dehydrogenase Type 2 antibodyAnti-11-Dh2 antibodyAnti-11-Beta-Hsd2 antibodyAnti-11-Beta-Hydroxysteroid Dehydrogenase Type Ii antibodyAnti-11-Hsd Type Ii antibodyAnti-11-Beta-Hsd Type Ii antibodyAnti-Corticosteroid 11-Beta-Dehydrogenase Isozyme 2 antibodyAnti-Nad-Dependent 11-Beta-Hydroxysteroid Dehydrogenase antibodyAnti-Short Chain Dehydrogenase/Reductase Family 9c Member 3 antibodyAnti-HSD11B2 antibodyAnti-HSD11K antibodyAnti-SDR9C3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
