| Post Translational Modifications | Autophosphorylates: phosphorylation promotes ubiquitination by the Cul7-RING(FBXW8) ubiquitin-protein ligase complex, leading to its degradation by the proteasome. Tyrosine-phosphorylated after activation of hemopoietic cells. Ubiquitinated by the Cul7-RING(FBXW8) ubiquitin-protein ligase complex following autophosphorylation, leading to its degradation by the proteasome. |
| Function | Serine/threonine-protein kinase, which plays a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway. May play a role in hematopoietic lineage decisions and growth regulation. Together with CLNK, it enhances CD3-triggered activation of T-cells and subsequent IL2 production. |
| Protein Name | Mitogen-Activated Protein Kinase Kinase Kinase Kinase 1Hematopoietic Progenitor KinaseMapk/Erk Kinase Kinase Kinase 1Mek Kinase Kinase 1Mekkk 1 |
| Alternative Antibody Names | Anti-Mitogen-Activated Protein Kinase Kinase Kinase Kinase 1 antibodyAnti-Hematopoietic Progenitor Kinase antibodyAnti-Mapk/Erk Kinase Kinase Kinase 1 antibodyAnti-Mek Kinase Kinase 1 antibodyAnti-Mekkk 1 antibodyAnti-MAP4K1 antibodyAnti-HPK1 antibody |
Information sourced from Uniprot.org
