| Host: |
Goat |
| Applications: |
Pep-ELISA/WB/IHC |
| Reactivity: |
Human/Mouse/Rat/Dog/Pig/Cow |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Goat polyclonal antibody anti-HPK1/MAP4K1 (N-Term) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: |
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: |
0.5 mg/mL |
| Dilution Range: |
WB-Recommended for use at 0.5-2µg/mlIHC-2.5µg/mlELISA-antibody detection limit dilution 1:32000. |
| Storage Instruction: |
Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: |
MAP4K1 |
| Gene ID: |
11184 |
| Uniprot ID: |
M4K1_HUMAN |
| Immunogen Region: |
N-Term |
| Accession Number: |
NP_001036065.1; NP_009112.1 |
| Specificity: |
This antibody is expected to recognise isoform 1 (NP_001036065.1) and isoform 2 (NP_009112.1). |
| Immunogen Sequence: |
DVVDPDIFNRDPR |
| Post Translational Modifications | Autophosphorylates: phosphorylation promotes ubiquitination by the Cul7-RING(FBXW8) ubiquitin-protein ligase complex, leading to its degradation by the proteasome. Tyrosine-phosphorylated after activation of hemopoietic cells. Ubiquitinated by the Cul7-RING(FBXW8) ubiquitin-protein ligase complex following autophosphorylation, leading to its degradation by the proteasome. |
| Function | Serine/threonine-protein kinase, which may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in hematopoietic lineage decisions and growth regulation. Able to autophosphorylate. Together with CLNK, it enhances CD3-triggered activation of T-cells and subsequent IL2 production. |
| Protein Name | Mitogen-Activated Protein Kinase Kinase Kinase Kinase 1Hematopoietic Progenitor KinaseMapk/Erk Kinase Kinase Kinase 1Mek Kinase Kinase 1Mekkk 1 |
| Alternative Antibody Names | Anti-Mitogen-Activated Protein Kinase Kinase Kinase Kinase 1 antibodyAnti-Hematopoietic Progenitor Kinase antibodyAnti-Mapk/Erk Kinase Kinase Kinase 1 antibodyAnti-Mek Kinase Kinase 1 antibodyAnti-Mekkk 1 antibodyAnti-MAP4K1 antibodyAnti-HPK1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
