Anti-HMGCS2 antibody (269-508) (STJ116457)

Name: Anti-HMGCS2 antibody (269-508) (STJ116457)
SKU: STJ116457
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityPolyclonal

HostRabbit

ConjugationUnconjugated

IsotypeIgG

STJ116457

Current Stock:

🚚 Free UK Delivery on orders over £150

Quantity:

Processing The item has been added

Enquire For Bulk Order

✓ 1-Year Performance Guarantee | SDS & Datasheet Included | Expert Tech Support | Covered by St John's Laboratory Guarantee

Short Description	Rabbit polyclonal HMGCS2 (269-508) antibody for use in WB, IHC-P, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents.
Applications	WB/IHC-P/IF/ICC/ELISA
Host	Rabbit
Reactivity	Human/Mouse/Rat
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Polyclonal
Isotype	IgG
Conjugation	Unconjugated
Concentration	Lot specific
Purification	Affinity purification
Dilution Range	WB:1:2000-1:8000 IHC-P:1:50-1:100 IF/ICC:1:50-1:100 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Formulation	PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3.
Storage Instruction	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol	HMGCS2
Gene ID	3158
Uniprot ID	HMCS2_HUMAN
Immunogen Region	269-508
Immunogen Sequence	CYTSYRKKIQNQWKQAGSDR PFTLDDLQYMIFHTPFCKMV QKSLARLMFNDFLSASSDTQ TSLYKGLEAFGGLKLEDTYT NKDLDKALLKASQDMFDKKT KASLYLSTHNGNMYTSSLYG CLASLLSHHSAQELAGSRIG AFSYGSGLAASFFSFRVSQD AAPGSPLDKLVSSTSDLPKR LASRKCVSPEEFTEIMNQRE QFYHKVNFSPPGDTNSLFPG TWYLERVDEQHRRKYARRP
Specificity	Recombinant fusion protein containing a sequence corresponding to amino acids 269-508 of human HMGCS2 (NP_005509.1).

Tissue Specificity	Expression in liver is 200-fold higher than in any other tissue. Low expression in colon, kidney, testis, and pancreas. Very low expression in heart and skeletal muscle. Not detected in brain. Isoform 3: Highest expression detected in heart and skeletal muscle.
Post Translational Modifications	Succinylated. Desuccinylated by SIRT5. Succinylation, at least at Lys-83 and Lys-310, inhibits the enzymatic activity.
Function	Catalyzes the first irreversible step in ketogenesis, condensing acetyl-CoA to acetoacetyl-CoA to form HMG-CoA, which is converted by HMG-CoA reductase (HMGCR) into mevalonate.
Protein Name	Hydroxymethylglutaryl-Coa Synthase - Mitochondrial Hmg-Coa Synthase 3-Hydroxy-3-Methylglutaryl Coenzyme A Synthase
Database Links	Reactome: R-HSA-1989781 Reactome: R-HSA-77111 Reactome: R-HSA-9837999
Cellular Localisation	Mitochondrion
Alternative Antibody Names	Anti-Hydroxymethylglutaryl-Coa Synthase - Mitochondrial antibody Anti-Hmg-Coa Synthase antibody Anti-3-Hydroxy-3-Methylglutaryl Coenzyme A Synthase antibody Anti-HMGCS2 antibody

Information sourced from Uniprot.org