Anti-HMGCS1 antibody (241-520) (STJ24047)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal HMGCS1 (241-520) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:1000-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | HMGCS1 |
| Gene ID | 3157 |
| Uniprot ID | HMCS1_HUMAN |
| Immunogen Region | 241-520 |
| Immunogen Sequence | HAQWQKEGNDKDFTLNDFGF MIFHSPYCKLVQKSLARMLL NDFLNDQNRDKNSIYSGLEA FGDVKLEDTYFDRDVEKAFM KASSELFSQKTKASLLVSNQ NGNMYTSSVYGSLASVLAQY SPQQLAGKRIGVFSYGSGLA ATLYSLKVTQDATPGSALDK ITASLCDLKSRLDSRTGVAP DVFAENMKLREDTHHLVNYI PQGSIDSLFEGTWYLVRVDE KHRRTYARRPTPNDDTLDE |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 241-520 of human HMGCS1 (NP_002121.4). |
Additional Info
| Function | Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is converted by HMG-CoA reductase (HMGCR) into mevalonate, a precursor for cholesterol synthesis. |
| Protein Name | Hydroxymethylglutaryl-Coa Synthase - CytoplasmicHmg-Coa Synthase3-Hydroxy-3-Methylglutaryl Coenzyme A Synthase |
| Database Links | Reactome: R-HSA-191273Reactome: R-HSA-1989781Reactome: R-HSA-2426168 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Hydroxymethylglutaryl-Coa Synthase - Cytoplasmic antibodyAnti-Hmg-Coa Synthase antibodyAnti-3-Hydroxy-3-Methylglutaryl Coenzyme A Synthase antibodyAnti-HMGCS1 antibodyAnti-HMGCS antibody |
Information sourced from Uniprot.org