| Host: |
Rabbit |
| Applications: |
IHC/WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Hydroxymethylglutaryl-CoA lyase, mitochondrial (C-Term) is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000IHC 1:50-200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
HMGCL |
| Gene ID: |
3155 |
| Uniprot ID: |
HMGCL_HUMAN |
| Immunogen Region: |
C-Term |
| Specificity: |
This antibody detects endogenous levels of HMGCL at Human, Mouse, Rat |
| Immunogen: |
Synthesized peptide derived from human C-ternal HMGCL |
| Function | Mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis. Terminal step in leucine catabolism. Ketone bodies (beta-hydroxybutyrate, acetoacetate and acetone) are essential as an alternative source of energy to glucose, as lipid precursors and as regulators of metabolism. |
| Protein Name | Hydroxymethylglutaryl-Coa Lyase - MitochondrialHlHmg-Coa Lyase3-Hydroxy-3-Methylglutarate-Coa Lyase |
| Database Links | Reactome: R-HSA-77111Reactome: R-HSA-9033241 |
| Cellular Localisation | Mitochondrion MatrixPeroxisomeUnprocessed Form Is Peroxisomal |
| Alternative Antibody Names | Anti-Hydroxymethylglutaryl-Coa Lyase - Mitochondrial antibodyAnti-Hl antibodyAnti-Hmg-Coa Lyase antibodyAnti-3-Hydroxy-3-Methylglutarate-Coa Lyase antibodyAnti-HMGCL antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
