Host: | Rabbit |
Applications: | IHC/WB |
Reactivity: | Human/Mouse/Rat |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Rabbit polyclonal antibody anti-Hydroxymethylglutaryl-CoA lyase, mitochondrial (C-Term) is suitable for use in Immunohistochemistry and Western Blot research applications. |
Clonality: | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Concentration: | 1 mg/mL |
Dilution Range: | WB 1:500-2000 IHC 1:50-200 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | HMGCL |
Gene ID: | 3155 |
Uniprot ID: | HMGCL_HUMAN |
Immunogen Region: | C-Term |
Specificity: | This antibody detects endogenous levels of HMGCL at Human, Mouse, Rat |
Immunogen: | Synthesized peptide derived from human C-ternal HMGCL |
Function | Mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis. Terminal step in leucine catabolism. Ketone bodies (beta-hydroxybutyrate, acetoacetate and acetone) are essential as an alternative source of energy to glucose, as lipid precursors and as regulators of metabolism. |
Protein Name | Hydroxymethylglutaryl-Coa Lyase - Mitochondrial Hl Hmg-Coa Lyase 3-Hydroxy-3-Methylglutarate-Coa Lyase |
Database Links | Reactome: R-HSA-77111 Reactome: R-HSA-9033241 |
Cellular Localisation | Mitochondrion Matrix Peroxisome Unprocessed Form Is Peroxisomal |
Alternative Antibody Names | Anti-Hydroxymethylglutaryl-Coa Lyase - Mitochondrial antibody Anti-Hl antibody Anti-Hmg-Coa Lyase antibody Anti-3-Hydroxy-3-Methylglutarate-Coa Lyase antibody Anti-HMGCL antibody |
Information sourced from Uniprot.org