• Western blot analysis of lysates from HpeG2 cells, primary antibody was diluted at 1:1000, 4°C over night

Anti-HMBOX1 antibody (169-219 aa) (STJ194892)

SKU:
STJ194892

Current Stock:
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Homeobox-containing protein 1 (169-219 aa) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: HMBOX1
Gene ID: 79618
Uniprot ID: HMBX1_HUMAN
Immunogen Region: 169-219 aa
Specificity: This antibody detects endogenous levels of HMBX1 at Human/Mouse
Immunogen: Synthesized peptide derived from the human HMBX1 at the amino acid range 169-219
Function Binds directly to 5'-TTAGGG-3' repeats in telomeric DNA. Associates with the telomerase complex at sites of active telomere processing and positively regulates telomere elongation. Important for TERT binding to chromatin, indicating a role in recruitment of the telomerase complex to telomeres. Also plays a role in the alternative lengthening of telomeres (ALT) pathway in telomerase-negative cells where it promotes formation and/or maintenance of ALT-associated promyelocytic leukemia bodies (APBs). Enhances formation of telomere C-circles in ALT cells, suggesting a possible role in telomere recombination. Might also be involved in the DNA damage response at telomeres.
Protein Name Homeobox-Containing Protein 1
Homeobox Telomere-Binding Protein 1
Telomere-Associated Homeobox-Containing Protein 1
Cellular Localisation Nucleus
Cytoplasm
Chromosome
Telomere
Cajal Body
Pml Body
Predominantly Detected In Cytoplasm
Localizes In A Dynamic Manner To Actively Processed Telomeres
Localizes To The Periphery Of Cajal Bodies
Associates With Pml Nuclear Bodies In Telomerase-Negative Cells
Isoform 5: Nucleus
Alternative Antibody Names Anti-Homeobox-Containing Protein 1 antibody
Anti-Homeobox Telomere-Binding Protein 1 antibody
Anti-Telomere-Associated Homeobox-Containing Protein 1 antibody
Anti-HMBOX1 antibody
Anti-HOT1 antibody
Anti-TAH1 antibody

Information sourced from Uniprot.org

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