Host: |
Rabbit |
Applications: |
WB |
Reactivity: |
Human/Mouse |
Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: |
Rabbit polyclonal antibody anti-Homeobox-containing protein 1 (169-219 aa) is suitable for use in Western Blot research applications. |
Clonality: |
Polyclonal |
Conjugation: |
Unconjugated |
Isotype: |
IgG |
Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Concentration: |
1 mg/mL |
Dilution Range: |
WB 1:500-2000 |
Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: |
HMBOX1 |
Gene ID: |
79618 |
Uniprot ID: |
HMBX1_HUMAN |
Immunogen Region: |
169-219 aa |
Specificity: |
This antibody detects endogenous levels of HMBX1 at Human/Mouse |
Immunogen: |
Synthesized peptide derived from the human HMBX1 at the amino acid range 169-219 |
Function | Binds directly to 5'-TTAGGG-3' repeats in telomeric DNA. Associates with the telomerase complex at sites of active telomere processing and positively regulates telomere elongation. Important for TERT binding to chromatin, indicating a role in recruitment of the telomerase complex to telomeres. Also plays a role in the alternative lengthening of telomeres (ALT) pathway in telomerase-negative cells where it promotes formation and/or maintenance of ALT-associated promyelocytic leukemia bodies (APBs). Enhances formation of telomere C-circles in ALT cells, suggesting a possible role in telomere recombination. Might also be involved in the DNA damage response at telomeres. |
Protein Name | Homeobox-Containing Protein 1Homeobox Telomere-Binding Protein 1Telomere-Associated Homeobox-Containing Protein 1 |
Cellular Localisation | NucleusCytoplasmChromosomeTelomereCajal BodyPml BodyPredominantly Detected In CytoplasmLocalizes In A Dynamic Manner To Actively Processed TelomeresLocalizes To The Periphery Of Cajal BodiesAssociates With Pml Nuclear Bodies In Telomerase-Negative CellsIsoform 5: Nucleus |
Alternative Antibody Names | Anti-Homeobox-Containing Protein 1 antibodyAnti-Homeobox Telomere-Binding Protein 1 antibodyAnti-Telomere-Associated Homeobox-Containing Protein 1 antibodyAnti-HMBOX1 antibodyAnti-HOT1 antibodyAnti-TAH1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance