| Host: |
Rabbit |
| Applications: |
IHC/WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-HLTF (400-450 aa) is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Lyophilised |
| Purification: |
IgG purified |
| Dilution Range: |
IHC, WB (confirmed by recombinant protein). A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Storage Instruction: |
Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: |
HLTF |
| Gene ID: |
6596 |
| Uniprot ID: |
HLTF_HUMAN |
| Immunogen Region: |
400-450 aa |
| Specificity: |
Specific for HLTF. |
| Immunogen: |
A synthetic peptide from aa region 400-450 of human HLTF conjugated to an immunogenic carrier protein was used as the antigen. |
| Function | Has both helicase and E3 ubiquitin ligase activities. Possesses intrinsic ATP-dependent nucleosome-remodeling activity.This activity may be required for transcriptional activation or repression of specific target promoters. These may include the SERPINE1 and HIV-1 promoters and the SV40 enhancer, to which this protein can bind directly. Plays a role in error-free postreplication repair (PRR) of damaged DNA and maintains genomic stability through acting as a ubiquitin ligase for 'Lys-63'-linked polyubiquitination of chromatin-bound PCNA. |
| Protein Name | Helicase-Like Transcription FactorDna-Binding Protein/Plasminogen Activator Inhibitor 1 RegulatorHip116Ring Finger Protein 80Ring-Type E3 Ubiquitin Transferase HltfSwi/Snf-Related Matrix-Associated Actin-Dependent Regulator Of Chromatin Subfamily A Member 3Sucrose Nonfermenting Protein 2-Like 3 |
| Database Links | Reactome: R-HSA-8866654 |
| Cellular Localisation | CytoplasmNucleusNucleolusNucleoplasmNuclear Localization Is Stimulated By Progesterone |
| Alternative Antibody Names | Anti-Helicase-Like Transcription Factor antibodyAnti-Dna-Binding Protein/Plasminogen Activator Inhibitor 1 Regulator antibodyAnti-Hip116 antibodyAnti-Ring Finger Protein 80 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Hltf antibodyAnti-Swi/Snf-Related Matrix-Associated Actin-Dependent Regulator Of Chromatin Subfamily A Member 3 antibodyAnti-Sucrose Nonfermenting Protein 2-Like 3 antibodyAnti-HLTF antibodyAnti-HIP116A antibodyAnti-RNF80 antibodyAnti-SMARCA3 antibodyAnti-SNF2L3 antibodyAnti-ZBU1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
