Anti-HLTF antibody (400-450 aa) (STJ13101236)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide from aa region 400-450 of human HLTF conjugated to an immunogenic carrier protein was used as the antigen.
General Information
| Short Description | Rabbit polyclonal anti-HLTF (400-450 aa) for use in IHC and WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | IgG purified |
| Dilution Range | IHC, WB (confirmed by recombinant protein). A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Formulation | Lyophilised |
| Storage Instruction | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
Target Information
| Gene Symbol | HLTF |
| Gene ID | 6596 |
| Uniprot ID | HLTF_HUMAN |
| Immunogen | A synthetic peptide from aa region 400-450 of human HLTF conjugated to an immunogenic carrier protein was used as the antigen. |
| Immunogen Region | 400-450 aa |
| Specificity | Specific for HLTF. |
Additional Info
| Function | Has both helicase and E3 ubiquitin ligase activities. Possesses intrinsic ATP-dependent nucleosome-remodeling activity.This activity may be required for transcriptional activation or repression of specific target promoters. These may include the SERPINE1 and HIV-1 promoters and the SV40 enhancer, to which this protein can bind directly. Plays a role in error-free postreplication repair (PRR) of damaged DNA and maintains genomic stability through acting as a ubiquitin ligase for 'Lys-63'-linked polyubiquitination of chromatin-bound PCNA. |
| Protein Name | Helicase-Like Transcription FactorDna-Binding Protein/Plasminogen Activator Inhibitor 1 RegulatorHip116Ring Finger Protein 80Ring-Type E3 Ubiquitin Transferase HltfSwi/Snf-Related Matrix-Associated Actin-Dependent Regulator Of Chromatin Subfamily A Member 3Sucrose Nonfermenting Protein 2-Like 3 |
| Database Links | Reactome: R-HSA-8866654 |
| Cellular Localisation | CytoplasmNucleusNucleolusNucleoplasmNuclear Localization Is Stimulated By Progesterone |
| Alternative Antibody Names | Anti-Helicase-Like Transcription Factor antibodyAnti-Dna-Binding Protein/Plasminogen Activator Inhibitor 1 Regulator antibodyAnti-Hip116 antibodyAnti-Ring Finger Protein 80 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Hltf antibodyAnti-Swi/Snf-Related Matrix-Associated Actin-Dependent Regulator Of Chromatin Subfamily A Member 3 antibodyAnti-Sucrose Nonfermenting Protein 2-Like 3 antibodyAnti-HLTF antibodyAnti-HIP116A antibodyAnti-RNF80 antibodyAnti-SMARCA3 antibodyAnti-SNF2L3 antibodyAnti-ZBU1 antibody |
Information sourced from Uniprot.org