Anti-HLA DMB antibody [R24-3U-2] (STJA0035536)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthesized peptide derived from human HLA DMB
General Information
| Short Description | Rabbit monoclonal anti-HLA DMB for use in WB and FC in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/FC |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R24-3U-2 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity Chromatography |
| Dilution Range | WB 1:500-1:1000FC 1:50 |
| Formulation | Liquid in PBS, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | HLA-DMB |
| Gene ID | 3109 |
| Uniprot ID | DMB_HUMAN |
| Immunogen | A synthesized peptide derived from human HLA DMB |
Additional Info
| Function | Plays a critical role in catalyzing the release of class II-associated invariant chain peptide (CLIP) from newly synthesized MHC class II molecules and freeing the peptide binding site for acquisition of antigenic peptides. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. |
| Protein Name | Hla Class Ii Histocompatibility Antigen - Dm Beta ChainMhc Class Ii Antigen DmbReally Interesting New Gene 7 Protein |
| Database Links | Reactome: R-HSA-2132295 |
| Cellular Localisation | Late Endosome MembraneSingle-Pass Type I Membrane ProteinLysosome MembraneLocalizes To Late Endocytic CompartmentAssociates With Lysosome Membranes |
| Alternative Antibody Names | Anti-Hla Class Ii Histocompatibility Antigen - Dm Beta Chain antibodyAnti-Mhc Class Ii Antigen Dmb antibodyAnti-Really Interesting New Gene 7 Protein antibodyAnti-HLA-DMB antibodyAnti-DMB antibodyAnti-RING7 antibody |
Information sourced from Uniprot.org