Anti-HEXIM1 antibody (C-Term) (STJ70792)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-HEXIM1 (C-Term) is suitable for use in ELISA, Western Blot and Immunofluorescence research applications. |
| Applications | Pep-ELISA/WB/IF |
| Host | Goat |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:128000.WB: Approx 40kDa band observed in Human and Mouse Heart lysates (calculated MW of 40.6kDa according to Human NP_006451.1 and 40.2kDa according to Mouse NP_620092.1. Recommended concentrat |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | HEXIM1 |
| Gene ID | 10614 |
| Uniprot ID | HEXI1_HUMAN |
| Accession Number | NP_006451.1 |
| Immunogen Region | C-Term |
| Immunogen Sequence | HRQQERAPLSKFGD |
Additional Info
| Function | Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. Core component of the 7SK RNP complex: in cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway. |
| Protein Name | Protein Hexim1Cardiac Lineage Protein 1Estrogen Down-Regulated Gene 1 ProteinHexamethylene Bis-Acetamide-Inducible Protein 1Menage A Quatre Protein 1 |
| Cellular Localisation | NucleusCytoplasmBinds Alpha-Importin And Is Mostly Nuclear |
| Alternative Antibody Names | Anti-Protein Hexim1 antibodyAnti-Cardiac Lineage Protein 1 antibodyAnti-Estrogen Down-Regulated Gene 1 Protein antibodyAnti-Hexamethylene Bis-Acetamide-Inducible Protein 1 antibodyAnti-Menage A Quatre Protein 1 antibodyAnti-HEXIM1 antibodyAnti-CLP1 antibodyAnti-EDG1 antibodyAnti-HIS1 antibodyAnti-MAQ1 antibody |
Information sourced from Uniprot.org