• STJ70792 (0. 1µg/ml) staining of Human (A) and Mouse (B) Heart lysates (35µg protein in RIPA buffer). Detected by chemiluminescence.
  • STJ70792 Immunofluorescence analysis of paraformaldehyde fixed A431 cells, permeabilized with 0. 15% Triton. Primary incubation 1hr (10ug/ml) followed by Alexa Fluor 488 secondary antibody (2ug/ml) , showing nuclear staining. The nuclear stain is DAPI (blue). NA NA NA Negative control: Unimmunized goat IgG (10ug/ml) followed by Alexa Fluor 488 secondary antibody (2ug/ml).
  • STJ70792 Immunofluorescence analysis of paraformaldehyde fixed HeLa cells, permeabilized with 0. 15% Triton. Primary incubation 1hr (10ug/ml) followed by Alexa Fluor 488 secondary antibody (2ug/ml) , showing nuclear staining. The nuclear stain is DAPI (blue). NA NA NA Negative control: Unimmunized goat IgG (10ug/ml) followed by Alexa Fluor 488 secondary antibody (2ug/ml).

Anti-HEXIM1 antibody (C-Term) (STJ70792)

SKU:
STJ70792-100

£303.50
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Host: Goat
Applications: Pep-ELISA/IF/WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Goat polyclonal antibody anti-HEXIM1 (C-Term) is suitable for use in ELISA, Immunofluorescence and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 0.5 mg/mL
Dilution Range: WB-0.1-0.3µg/ml
IF-Strong expression of the protein seen in the nucleus of A431 and HeLa cells. 10µg/ml
ELISA-antibody detection limit dilution 1:128000.
Storage Instruction: Store at-20°C on receipt and minimise freeze-thaw cycles.
Gene Symbol: HEXIM1
Gene ID: 10614
Uniprot ID: HEXI1_HUMAN
Immunogen Region: C-Term
Accession Number: NP_006451.1
Immunogen Sequence: HRQQERAPLSKFGD
Function Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. Core component of the 7SK RNP complex: in cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway.
Protein Name Protein Hexim1
Cardiac Lineage Protein 1
Estrogen Down-Regulated Gene 1 Protein
Hexamethylene Bis-Acetamide-Inducible Protein 1
Menage A Quatre Protein 1
Cellular Localisation Nucleus
Cytoplasm
Binds Alpha-Importin And Is Mostly Nuclear
Alternative Antibody Names Anti-Protein Hexim1 antibody
Anti-Cardiac Lineage Protein 1 antibody
Anti-Estrogen Down-Regulated Gene 1 Protein antibody
Anti-Hexamethylene Bis-Acetamide-Inducible Protein 1 antibody
Anti-Menage A Quatre Protein 1 antibody
Anti-HEXIM1 antibody
Anti-CLP1 antibody
Anti-EDG1 antibody
Anti-HIS1 antibody
Anti-MAQ1 antibody

Information sourced from Uniprot.org

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