Host: |
Goat |
Applications: |
Pep-ELISA/IF/WB |
Reactivity: |
Human/Mouse |
Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: |
Goat polyclonal antibody anti-HEXIM1 (C-Term) is suitable for use in ELISA, Immunofluorescence and Western Blot research applications. |
Clonality: |
Polyclonal |
Conjugation: |
Unconjugated |
Isotype: |
IgG |
Formulation: |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
Purification: |
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
Concentration: |
0.5 mg/mL |
Dilution Range: |
WB-0.1-0.3µg/mlIF-Strong expression of the protein seen in the nucleus of A431 and HeLa cells. 10µg/mlELISA-antibody detection limit dilution 1:128000. |
Storage Instruction: |
Store at-20°C on receipt and minimise freeze-thaw cycles. |
Gene Symbol: |
HEXIM1 |
Gene ID: |
10614 |
Uniprot ID: |
HEXI1_HUMAN |
Immunogen Region: |
C-Term |
Accession Number: |
NP_006451.1 |
Immunogen Sequence: |
HRQQERAPLSKFGD |
Function | Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. Core component of the 7SK RNP complex: in cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway. |
Protein Name | Protein Hexim1Cardiac Lineage Protein 1Estrogen Down-Regulated Gene 1 ProteinHexamethylene Bis-Acetamide-Inducible Protein 1Menage A Quatre Protein 1 |
Cellular Localisation | NucleusCytoplasmBinds Alpha-Importin And Is Mostly Nuclear |
Alternative Antibody Names | Anti-Protein Hexim1 antibodyAnti-Cardiac Lineage Protein 1 antibodyAnti-Estrogen Down-Regulated Gene 1 Protein antibodyAnti-Hexamethylene Bis-Acetamide-Inducible Protein 1 antibodyAnti-Menage A Quatre Protein 1 antibodyAnti-HEXIM1 antibodyAnti-CLP1 antibodyAnti-EDG1 antibodyAnti-HIS1 antibodyAnti-MAQ1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance