Anti-HEXIM1 antibody (210-359) (STJ28342)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal HEXIM1 (210-359) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | HEXIM1 |
| Gene ID | 10614 |
| Uniprot ID | HEXI1_HUMAN |
| Immunogen Region | 210-359 |
| Immunogen Sequence | MDDHDQEEPDLKTGLYSKRA AAKSDDTSDDDFMEEGGEED GGSDGMGGDGSEFLQRDFSE TYERYHTESLQNMSKQELIK EYLELEKCLSRMEDENNRLR LESKRLGGDDARVRELELEL DRLRAENLQLLTENELHRQQ ERAPLSKFGD |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 210-359 of human HEXIM1 (NP_006451.1). |
Additional Info
| Tissue Specificity | Ubiquitously expressed with higher expression in placenta. HEXIM1 and HEXIM2 are differentially expressed. Expressed in endocrine tissues. |
| Function | Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. Core component of the 7SK RNP complex: in cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway. |
| Protein Name | Protein Hexim1Cardiac Lineage Protein 1Estrogen Down-Regulated Gene 1 ProteinHexamethylene Bis-Acetamide-Inducible Protein 1Menage A Quatre Protein 1 |
| Database Links | |
| Cellular Localisation | NucleusCytoplasmBinds Alpha-Importin And Is Mostly Nuclear |
| Alternative Antibody Names | Anti-Protein Hexim1 antibodyAnti-Cardiac Lineage Protein 1 antibodyAnti-Estrogen Down-Regulated Gene 1 Protein antibodyAnti-Hexamethylene Bis-Acetamide-Inducible Protein 1 antibodyAnti-Menage A Quatre Protein 1 antibodyAnti-HEXIM1 antibodyAnti-CLP1 antibodyAnti-EDG1 antibodyAnti-HIS1 antibodyAnti-MAQ1 antibody |
Information sourced from Uniprot.org