| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Probable E3 ubiquitin-protein ligase HERC1 (509-559 aa) is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:1000-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | HERC1 |
| Gene ID: | 8925 |
| Uniprot ID: | HERC1_HUMAN |
| Immunogen Region: | 509-559 aa |
| Specificity: | This antibody detects endogenous levels of human HERC1 |
| Immunogen: | Synthesized peptide derived from the human HERC1 at the amino acid range 509-559 |
| Function | Involved in membrane trafficking via some guanine nucleotide exchange factor (GEF) activity and its ability to bind clathrin. Acts as a GEF for Arf and Rab, by exchanging bound GDP for free GTP. Binds phosphatidylinositol 4,5-bisphosphate, which is required for GEF activity. May also act as a E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. |
| Protein Name | Probable E3 Ubiquitin-Protein Ligase Herc1 Hect Domain And Rcc1-Like Domain-Containing Protein 1 Hect-Type E3 Ubiquitin Transferase Herc1 P532 P619 |
| Database Links | Reactome: R-HSA-983168 |
| Cellular Localisation | Membrane Peripheral Membrane Protein Cytoplasm Cytosol Golgi Apparatus Recruited Onto Actin-Rich Surface Protrusions |
| Alternative Antibody Names | Anti-Probable E3 Ubiquitin-Protein Ligase Herc1 antibody Anti-Hect Domain And Rcc1-Like Domain-Containing Protein 1 antibody Anti-Hect-Type E3 Ubiquitin Transferase Herc1 antibody Anti-P532 antibody Anti-P619 antibody Anti-HERC1 antibody |
Information sourced from Uniprot.org