Anti-HERC1 antibody (509-559 aa) (STJ197623)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human HERC1 at the amino acid range 509-559
General Information
| Short Description | Rabbit polyclonal anti-Probable E3 ubiquitin-protein ligase HERC1 (509-559 aa) for use in WB in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:1000-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | HERC1 |
| Gene ID | 8925 |
| Uniprot ID | HERC1_HUMAN |
| Immunogen | Synthesized peptide derived from the human HERC1 at the amino acid range 509-559 |
| Immunogen Region | 509-559 aa |
| Specificity | This antibody detects endogenous levels of human HERC1 |
Additional Info
| Function | Involved in membrane trafficking via some guanine nucleotide exchange factor (GEF) activity and its ability to bind clathrin. Acts as a GEF for Arf and Rab, by exchanging bound GDP for free GTP. Binds phosphatidylinositol 4,5-bisphosphate, which is required for GEF activity. May also act as a E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. |
| Protein Name | Probable E3 Ubiquitin-Protein Ligase Herc1Hect Domain And Rcc1-Like Domain-Containing Protein 1Hect-Type E3 Ubiquitin Transferase Herc1P532P619 |
| Database Links | Reactome: R-HSA-983168 |
| Cellular Localisation | MembranePeripheral Membrane ProteinCytoplasmCytosolGolgi ApparatusRecruited Onto Actin-Rich Surface Protrusions |
| Alternative Antibody Names | Anti-Probable E3 Ubiquitin-Protein Ligase Herc1 antibodyAnti-Hect Domain And Rcc1-Like Domain-Containing Protein 1 antibodyAnti-Hect-Type E3 Ubiquitin Transferase Herc1 antibodyAnti-P532 antibodyAnti-P619 antibodyAnti-HERC1 antibody |
Information sourced from Uniprot.org