Anti-HEPACAM antibody (35-245) (STJ113194)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal HEPACAM (35-245) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | HEPACAM |
| Gene ID | 220296 |
| Uniprot ID | HECAM_HUMAN |
| Immunogen Region | 35-245 |
| Immunogen Sequence | NITSPVRLIHGTVGKSALLS VQYSSTSSDRPVVKWQLKRD KPVTVVQSIGTEVIGTLRPD YRDRIRLFENGSLLLSDLQL ADEGTYEVEISITDDTFTGE KTINLTVDVPISRPQVLVAS TTVLELSEAFTLNCSHENGT KPSYTWLKDGKPLLNDSRML LSPDQKVLTITRVLMEDDDL YSCMVENPISQGRSLPVKIT VYRRSSLYIIL |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 35-245 of human HEPACAM (NP_689935.2). |
Additional Info
| Post Translational Modifications | N-glycosylated. |
| Function | Involved in regulating cell motility and cell-matrix interactions. May inhibit cell growth through suppression of cell proliferation. In glia, associates and targets CLCN2 at astrocytic processes and myelinated fiber tracts where it may regulate transcellular chloride flux involved in neuron excitability. |
| Protein Name | Hepatic And Glial Cell Adhesion MoleculeGlialcamHepatocyte Cell Adhesion MoleculeProtein Hepacam |
| Database Links | |
| Cellular Localisation | CytoplasmCell MembraneSingle-Pass Type I Membrane ProteinCytoplasmic SideColocalizes With Clcn2 At Astrocyte End-Foot In Contact With Brain Capillaries And Other Glial CellsIn Mcf-7 Breast Carcinoma And Hepatic Hep 3b21-7 And Hep-G2 Cell LinesLocalization Of Hepacam Is Cell Density-DependentIn Well Spread CellsLocalized To Punctate Structures In The Perinuclear MembraneAnd At Cell Surface Of ProtusionsIn Confluent CellsLocalized Predominantly To The Cytoplasmic MembraneParticularly In Areas Of Cell-Cell ContactsColocalizes With Cdh1 |
| Alternative Antibody Names | Anti-Hepatic And Glial Cell Adhesion Molecule antibodyAnti-Glialcam antibodyAnti-Hepatocyte Cell Adhesion Molecule antibodyAnti-Protein Hepacam antibodyAnti-HEPACAM antibody |
Information sourced from Uniprot.org