| Function | Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double-stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Plays a key role in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex: phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing.this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA. Its role in tRNA splicing and maturation is required for cerebellar development. Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation. Also phosphorylates the 5'-terminus of exogenously introduced short interfering RNAs (siRNAs), which is a necessary prerequisite for their incorporation into the RNA-induced silencing complex (RISC). However, endogenous siRNAs and microRNAs (miRNAs) that are produced by the cleavage of dsRNA precursors by DICER1 already contain a 5'-phosphate group, so this protein may be dispensible for normal RNA-mediated gene silencing. |
| Protein Name | Polyribonucleotide 5'-Hydroxyl-Kinase Clp1Polyadenylation Factor Clp1Polynucleotide Kinase Clp1Pre-Mrna Cleavage Complex Ii Protein Clp1 |
| Database Links | Reactome: R-HSA-6784531Reactome: R-HSA-72187Reactome: R-HSA-72203Reactome: R-HSA-73856Reactome: R-HSA-77595 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Polyribonucleotide 5'-Hydroxyl-Kinase Clp1 antibodyAnti-Polyadenylation Factor Clp1 antibodyAnti-Polynucleotide Kinase Clp1 antibodyAnti-Pre-Mrna Cleavage Complex Ii Protein Clp1 antibodyAnti-CLP1 antibodyAnti-HEAB antibody |
Information sourced from Uniprot.org
