• Western blot analysis of lysates from HeLa cells, using HDAC6 Antibody. The lane on the right is blocked with the synthesized peptide.
  • Western blot analysis of MCF7 cells using Histone deacetylase 6 Polyclonal Antibody diluted at 1:2000
  • Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue, using HDAC6 Antibody. The picture on the right is blocked with the synthesized peptide.
  • Western blot analysis of various cells using Histone deacetylase 6 Polyclonal Antibody diluted at 1:2000

Anti-HDAC6 antibody (1166-1215 aa) (STJ93512)

SKU:
STJ93512

Current Stock:
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Histone deacetylase 6 (1166-1215 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC 1:100-1:300
IF 1:200-1:1000
ELISA 1:20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: HDAC6
Gene ID: 10013
Uniprot ID: HDAC6_HUMAN
Immunogen Region: 1166-1215 aa
Specificity: Histone deacetylase 6 Polyclonal Antibody detects endogenous levels of Histone deacetylase 6 protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human HDAC6 at the amino acid range 1166-1215
Function Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. In addition to histones, deacetylates other proteins: plays a central role in microtubule-dependent cell motility by mediating deacetylation of tubulin. Required for cilia disassembly.via deacetylation of alpha-tubulin. Promotes deacetylation of CTTN, leading to actin polymerization, promotion of autophagosome-lysosome fusion and completion of autophagy. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Promotes odontoblast differentiation following IPO7-mediated nuclear import and subsequent repression of RUNX2 expression. In addition to its protein deacetylase activity, plays a key role in the degradation of misfolded proteins: when misfolded proteins are too abundant to be degraded by the chaperone refolding system and the ubiquitin-proteasome, mediates the transport of misfolded proteins to a cytoplasmic juxtanuclear structure called aggresome. Probably acts as an adapter that recognizes polyubiquitinated misfolded proteins and target them to the aggresome, facilitating their clearance by autophagy.
Protein Name Histone Deacetylase 6
Hd6
Tubulin-Lysine Deacetylase Hdac6
Database Links Reactome: R-HSA-2122947
Reactome: R-HSA-2644606
Reactome: R-HSA-2894862
Reactome: R-HSA-3371511
Reactome: R-HSA-350054
Reactome: R-HSA-5617833
Reactome: R-HSA-8878166
Reactome: R-HSA-8940973
Reactome: R-HSA-9613829
Reactome: R-HSA-9615710
Reactome: R-HSA-9646399
Cellular Localisation Cytoplasm
Cytoskeleton
Nucleus
Perikaryon
Cell Projection
Dendrite
Axon
Cilium
Microtubule Organizing Center
Centrosome
Cilium Basal Body
It Is Mainly Cytoplasmic
Where It Is Associated With Microtubules
Alternative Antibody Names Anti-Histone Deacetylase 6 antibody
Anti-Hd6 antibody
Anti-Tubulin-Lysine Deacetylase Hdac6 antibody
Anti-HDAC6 antibody
Anti-KIAA0901 antibody
Anti-JM21 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance