Anti-HAS3 antibody (STJA0007163)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human HAS3
General Information
| Short Description | Rabbit polyclonal anti-Hyaluronan synthase 3 for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20Β°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | HAS3 |
| Gene ID | 3038 |
| Uniprot ID | HYAS3_HUMAN |
| Immunogen | Synthesized peptide derived from human HAS3 |
| Specificity | This antibody detects endogenous levels of HAS3 at Human, Mouse |
Additional Info
| Function | Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of three isoenzymes responsible for cellular hyaluronan synthesis. |
| Protein Name | Hyaluronan Synthase 3Hyaluronate Synthase 3Hyaluronic Acid Synthase 3Ha Synthase 3 |
| Database Links | Reactome: R-HSA-2142850 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinGolgi Apparatus MembraneGolgi ApparatusTrans-Golgi Network MembraneEarly EndosomeTravels From Endoplasmic Reticulum (Er)Golgi To Plasma MembraneActives Only When Present In Plasma MembraneO-Glcnacylation Controls Its Membrane LocalizationA Rapid Recycling Of Has3 Between Plasma Membrane And Endosomes Is Controlled By The Cytosolic Levels Of Udp-Glcua And Udp-Glcnac |
| Alternative Antibody Names | Anti-Hyaluronan Synthase 3 antibodyAnti-Hyaluronate Synthase 3 antibodyAnti-Hyaluronic Acid Synthase 3 antibodyAnti-Ha Synthase 3 antibodyAnti-HAS3 antibody |
Information sourced from Uniprot.org