Anti-HAPSTR1 antibody (55-105 aa) (STJ194003)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human CP072 at the amino acid range 55-105
General Information
| Short Description | Rabbit polyclonal anti-HUWE1-associated protein modifying stress responses 1 (55-105 aa) for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | HAPSTR1 |
| Gene ID | 29035 |
| Uniprot ID | HAPR1_HUMAN |
| Immunogen | Synthesized peptide derived from the human CP072 at the amino acid range 55-105 |
| Immunogen Region | 55-105 aa |
| Specificity | This antibody detects endogenous levels of CP072 at Human/Mouse |
Additional Info
| Function | Acts as a central player within a network of stress response pathways promoting cellular adaptability. The E3 ligase HUWE1 assists HAPSTR1 in controlling stress signaling and in turn, HUWE1 feeds back to promote the degradation of HAPSTR1. HAPSTR1 represents a central coordination mechanism for stress response programs. Functions as a negative regulator of TP53/P53 in the cellular response to telomere erosion and probably also DNA damage. May attenuate p53/TP53 activation through the E3 ubiquitin ligase HUWE1. |
| Protein Name | Huwe1-Associated Protein Modifying Stress Responses 1Telomere Attrition And P53 Response 1 Protein |
| Database Links | |
| Cellular Localisation | NucleusCytoplasm |
| Alternative Antibody Names | Anti-Huwe1-Associated Protein Modifying Stress Responses 1 antibodyAnti-Telomere Attrition And P53 Response 1 Protein antibodyAnti-HAPSTR1 antibodyAnti-C16orf72 antibodyAnti-TAPR1 antibody |
Information sourced from Uniprot.org