Anti-HADH antibody (STJA0006880)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human HADH
General Information
| Short Description | Rabbit polyclonal anti-Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | HADH |
| Gene ID | 3033 |
| Uniprot ID | HCDH_HUMAN |
| Immunogen | Synthesized peptide derived from human HADH |
| Specificity | This antibody detects endogenous levels of HADH at Human, Mouse, Rat |
Additional Info
| Post Translational Modifications | Succinylation at Lys-81, adjacent to a coenzyme A binding site. Desuccinylated by SIRT5. |
| Function | Mitochondrial fatty acid beta-oxidation enzyme that catalyzes the third step of the beta-oxidation cycle for medium and short-chain 3-hydroxy fatty acyl-CoAs (C4 to C10). Plays a role in the control of insulin secretion by inhibiting the activation of glutamate dehydrogenase 1 (GLUD1), an enzyme that has an important role in regulating amino acid-induced insulin secretion. Plays a role in the maintenance of normal spermatogenesis through the reduction of fatty acid accumulation in the testes. |
| Protein Name | Hydroxyacyl-Coenzyme A Dehydrogenase - MitochondrialHcdhMedium And Short-Chain L-3-Hydroxyacyl-Coenzyme A DehydrogenaseShort-Chain 3-Hydroxyacyl-Coa Dehydrogenase |
| Database Links | Reactome: R-HSA-77310Reactome: R-HSA-77346Reactome: R-HSA-77348Reactome: R-HSA-77350Reactome: R-HSA-77352Reactome: R-HSA-9837999 |
| Cellular Localisation | Mitochondrion Matrix |
| Alternative Antibody Names | Anti-Hydroxyacyl-Coenzyme A Dehydrogenase - Mitochondrial antibodyAnti-Hcdh antibodyAnti-Medium And Short-Chain L-3-Hydroxyacyl-Coenzyme A Dehydrogenase antibodyAnti-Short-Chain 3-Hydroxyacyl-Coa Dehydrogenase antibodyAnti-HADH antibodyAnti-HAD antibodyAnti-HAD1 antibodyAnti-HADHSC antibodyAnti-SCHAD antibody |
Information sourced from Uniprot.org