| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | HADH |
| Gene ID: | 3033 |
| Uniprot ID: | HCDH_HUMAN |
| Specificity: | This antibody detects endogenous levels of HADH at Human, Mouse, Rat |
| Immunogen: | Synthesized peptide derived from human HADH |
| Post Translational Modifications | Succinylation at Lys-81, adjacent to a coenzyme A binding site. Desuccinylated by SIRT5. |
| Function | Mitochondrial fatty acid beta-oxidation enzyme that catalyzes the third step of the beta-oxidation cycle for medium and short-chain 3-hydroxy fatty acyl-CoAs (C4 to C10). Plays a role in the control of insulin secretion by inhibiting the activation of glutamate dehydrogenase 1 (GLUD1), an enzyme that has an important role in regulating amino acid-induced insulin secretion. Plays a role in the maintenance of normal spermatogenesis through the reduction of fatty acid accumulation in the testes. |
| Protein Name | Hydroxyacyl-Coenzyme A Dehydrogenase - Mitochondrial Hcdh Medium And Short-Chain L-3-Hydroxyacyl-Coenzyme A Dehydrogenase Short-Chain 3-Hydroxyacyl-Coa Dehydrogenase |
| Database Links | Reactome: R-HSA-77310 Reactome: R-HSA-77346 Reactome: R-HSA-77348 Reactome: R-HSA-77350 Reactome: R-HSA-77352 Reactome: R-HSA-9837999 |
| Cellular Localisation | Mitochondrion Matrix |
| Alternative Antibody Names | Anti-Hydroxyacyl-Coenzyme A Dehydrogenase - Mitochondrial antibody Anti-Hcdh antibody Anti-Medium And Short-Chain L-3-Hydroxyacyl-Coenzyme A Dehydrogenase antibody Anti-Short-Chain 3-Hydroxyacyl-Coa Dehydrogenase antibody Anti-HADH antibody Anti-HAD antibody Anti-HAD1 antibody Anti-HADHSC antibody Anti-SCHAD antibody |
Information sourced from Uniprot.org