| Tissue Specificity | Expressed in multiple tissues including heart, brain and kidney. |
| Post Translational Modifications | Autoubiquitinated. |
| Function | E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates postmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division. Specifically binds GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defense against pathogens. May also act as a transcription regulator via its interaction with RARB. |
| Protein Name | E3 Ubiquitin-Protein Ligase Hace1Hect Domain And Ankyrin Repeat-Containing E3 Ubiquitin-Protein Ligase 1Hect-Type E3 Ubiquitin Transferase Hace1 |
| Database Links | Reactome: R-HSA-983168 |
| Cellular Localisation | Golgi ApparatusGolgi Stack MembraneCytoplasmEndoplasmic ReticulumA Significant Portion Localizes To The Endoplasmic ReticulumTargeted To Golgi Membrane Via Its Interaction With Rab Proteins |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Hace1 antibodyAnti-Hect Domain And Ankyrin Repeat-Containing E3 Ubiquitin-Protein Ligase 1 antibodyAnti-Hect-Type E3 Ubiquitin Transferase Hace1 antibodyAnti-HACE1 antibodyAnti-KIAA1320 antibody |
Information sourced from Uniprot.org
