Anti-HACE1 IP antibody [SAA0202] (STJA0018717)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1
General Information
| Short Description | Mouse monoclonal E3 Ubiquitin-Protein Ligase Hace1 antibody for use in ELISA, IF and IP in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ELISA/IF/IP |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO) MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SAA0202 |
| Isotype | IgG1 |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Protein A/G purified from cell culture supernatant |
| Formulation | 0.01M PBS, pH 7.4. |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks For longer term store at-20°C for up to 12 months |
Target Information
| Gene Symbol | HACE1 |
| Gene ID | 57531 |
| Uniprot ID | HACE1_HUMAN |
Additional Info
| Post Translational Modifications | Autoubiquitinated. |
| Function | E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates postmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division. Specifically binds GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defense against pathogens. May also act as a transcription regulator via its interaction with RARB. |
| Protein Name | E3 Ubiquitin-Protein Ligase Hace1Hect Domain And Ankyrin Repeat-Containing E3 Ubiquitin-Protein Ligase 1Hect-Type E3 Ubiquitin Transferase Hace1 |
| Database Links | Reactome: R-HSA-983168 |
| Cellular Localisation | Golgi ApparatusGolgi Stack MembraneCytoplasmEndoplasmic ReticulumA Significant Portion Localizes To The Endoplasmic ReticulumTargeted To Golgi Membrane Via Its Interaction With Rab Proteins |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Hace1 antibodyAnti-Hect Domain And Ankyrin Repeat-Containing E3 Ubiquitin-Protein Ligase 1 antibodyAnti-Hect-Type E3 Ubiquitin Transferase Hace1 antibodyAnti-HACE1 antibodyAnti-KIAA1320 antibody |
Information sourced from Uniprot.org