| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-GZMA (29-262) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
GZMA |
| Gene ID: |
3001 |
| Uniprot ID: |
GRAA_HUMAN |
| Immunogen Region: |
29-262 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 29-262 of human GZMA (NP_006135.2). |
| Immunogen Sequence: |
IIGGNEVTPHSRPYMVLLSL DRKTICAGALIAKDWVLTAA HCNLNKRSQVILGAHSITRE EPTKQIMLVKKEFPYPCYDP ATREGDLKLLQLMEKAKINK YVTILHLPKKGDDVKPGTMC QVAGWGRTHNSASWSDTLRE VNITIIDRKVCNDRNHYNFN PVIGMNMVCAGSLRGGRDSC NGDSGSPLLCEGVFRGVTSF GLENKCGDPRGPGVYILLSK KHLNWIIMTIKGAV |
| Function | Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent pyroptosis when delivered into the target cell through the immunological synapse. It cleaves after Lys or Arg. Once delivered into the target cell, acts by catalyzing cleavage of gasdermin-B (GSDMB), releasing the pore-forming moiety of GSDMB, thereby triggering pyroptosis and target cell death. Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity. Cleaves the nucleosome assembly protein SET after 'Lys-189', which disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA. |
| Protein Name | Granzyme ACtl TryptaseCytotoxic T-Lymphocyte Proteinase 1Fragmentin-1Granzyme-1Hanukkah FactorH FactorHf |
| Cellular Localisation | Isoform Alpha: SecretedCytoplasmic GranuleDelivered Into The Target Cell By Perforin |
| Alternative Antibody Names | Anti-Granzyme A antibodyAnti-Ctl Tryptase antibodyAnti-Cytotoxic T-Lymphocyte Proteinase 1 antibodyAnti-Fragmentin-1 antibodyAnti-Granzyme-1 antibodyAnti-Hanukkah Factor antibodyAnti-H Factor antibodyAnti-Hf antibodyAnti-GZMA antibodyAnti-CTLA3 antibodyAnti-HFSP antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
