| Function | Regulator of post-transcriptional mitochondrial gene expression, required for assembly of the mitochondrial ribosome and for recruitment of mRNA and lncRNA. Binds RNAs containing the 14 base G-rich element. Preferentially binds RNAs transcribed from three contiguous genes on the light strand of mtDNA, the ND6 mRNA, and the long non-coding RNAs for MT-CYB and MT-ND5, each of which contains multiple consensus binding sequences. Involved in the degradosome-mediated decay of non-coding mitochondrial transcripts (MT-ncRNA) and tRNA-like molecules. Acts by unwinding G-quadruplex RNA structures in MT-ncRNA, thus facilitating their degradation by the degradosome. G-quadruplexes (G4) are non-canonical 4 stranded structures formed by transcripts from the light strand of mtDNA. |
| Protein Name | G-Rich Sequence Factor 1Grsf-1 |
| Database Links | Reactome: R-HSA-192823Reactome: R-HSA-9836573 |
| Cellular Localisation | Isoform 1: Mitochondrion MatrixLocalizes To Mitochondrial Rna Granules Found In Close Proximity To The Mitochondrial NucleoidsIsoform 2: Cytoplasm |
| Alternative Antibody Names | Anti-G-Rich Sequence Factor 1 antibodyAnti-Grsf-1 antibodyAnti-GRSF1 antibody |
Information sourced from Uniprot.org
