Anti-GRSF1 antibody (376-389 aa) [R06-2B5] (STJA0012397)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide of human GRSF1
General Information
| Short Description | Rabbit monoclonal anti-GRSF1 (376-389 aa) for use in WB, ICC and IF in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ICC/IF |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R06-2B5 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.3 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000IF 1:50-1:200 |
| Formulation | 50mM Tris-Glycine (pH7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Storage Instruction | Store at 4ยฐC short term. Aliquot and store at-20ยฐC long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | GRSF1 |
| Gene ID | 2926 |
| Uniprot ID | GRSF1_HUMAN |
| Immunogen | A synthetic peptide of human GRSF1 |
| Immunogen Region | 376-389 aa |
Additional Info
| Function | Regulator of post-transcriptional mitochondrial gene expression, required for assembly of the mitochondrial ribosome and for recruitment of mRNA and lncRNA. Binds RNAs containing the 14 base G-rich element. Preferentially binds RNAs transcribed from three contiguous genes on the light strand of mtDNA, the ND6 mRNA, and the long non-coding RNAs for MT-CYB and MT-ND5, each of which contains multiple consensus binding sequences. Involved in the degradosome-mediated decay of non-coding mitochondrial transcripts (MT-ncRNA) and tRNA-like molecules. Acts by unwinding G-quadruplex RNA structures in MT-ncRNA, thus facilitating their degradation by the degradosome. G-quadruplexes (G4) are non-canonical 4 stranded structures formed by transcripts from the light strand of mtDNA. |
| Protein Name | G-Rich Sequence Factor 1Grsf-1 |
| Database Links | Reactome: R-HSA-192823Reactome: R-HSA-9836573 |
| Cellular Localisation | Isoform 1: Mitochondrion MatrixLocalizes To Mitochondrial Rna Granules Found In Close Proximity To The Mitochondrial NucleoidsIsoform 2: Cytoplasm |
| Alternative Antibody Names | Anti-G-Rich Sequence Factor 1 antibodyAnti-Grsf-1 antibodyAnti-GRSF1 antibody |
Information sourced from Uniprot.org