| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | GRPEL2 |
| Gene ID: | 134266 |
| Uniprot ID: | GRPE2_HUMAN |
| Immunogen Region: | 33-225 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 33-225 of human GRPEL2 (NP_689620.2). |
| Immunogen Sequence: | STATQRTAGEDCRSEDPPDE LGPPLAERALRVKAVKLEKE VQDLTVRYQRAIADCENIRR RTQRCVEDAKIFGIQSFCKD LVEVADILEKTTECISEESE PEDQKLTLEKVFRGLLLLEA KLKSVFAKHGLEKLTPIGDK YDPHEHELICHVPAGVGVQP GTVALVRQDGYKLHGRTIRL ARVEVAVESQRRL |
| Function | Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins. Stimulates ATPase activity of mt-HSP70. May also serve to modulate the interconversion of oligomeric (inactive) and monomeric (active) forms of mt-HSP70. |
| Protein Name | Grpe Protein Homolog 2 - MitochondrialMt-Grpe#2 |
| Database Links | Reactome: R-HSA-1268020 |
| Cellular Localisation | Mitochondrion Matrix |
| Alternative Antibody Names | Anti-Grpe Protein Homolog 2 - Mitochondrial antibodyAnti-Mt-Grpe#2 antibodyAnti-GRPEL2 antibody |
Information sourced from Uniprot.org