Anti-GRM5 antibody (870-1212) (STJ111861)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal GRM5 (870-1212) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | GRM5 |
| Gene ID | 2915 |
| Uniprot ID | GRM5_HUMAN |
| Immunogen Region | 870-1212 |
| Immunogen Sequence | GSSGETLRYKDRRLAQHKSE IECFTPKGSMGNGGRATMSS SNGKSVTWAQNEKSSRGQHL WQRLSIHINKKENPNQTAVI KPFPKSTESRGLGAGAGAGG SAGGVGATGGAGCAGAGPGG PESPDAGPKALYDVAEAEEH FPAPARPRSPSPISTLSHRA GSASRTDDDVPSLHSEPVAR SSSSQGSLMEQISSVVTRFT A |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 870-1070 of human GRM5 (NP_001137303.1). |
Additional Info
| Function | G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. Plays an important role in the regulation of synaptic plasticity and the modulation of the neural network activity. |
| Protein Name | Metabotropic Glutamate Receptor 5Mglur5 |
| Database Links | Reactome: R-HSA-416476Reactome: R-HSA-420499Reactome: R-HSA-6794361 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Metabotropic Glutamate Receptor 5 antibodyAnti-Mglur5 antibodyAnti-GRM5 antibodyAnti-GPRC1E antibodyAnti-MGLUR5 antibody |
Information sourced from Uniprot.org